Stop in Syracuse, NY

Syracuse Regional Transportation Center

Adirondack Trailways, Amtrak, FlixBus, Greyhound and OurBus stop here: 289 departures a week to 63 cities and towns. The first departure leaves at 12:20 AM and the last at 10:50 PM.

Book on Adirondack Trailways (carrier website)

Timetable data from

Departures a week
289
Destinations
63
Bus and rail companies
5
Arrivals a week
287

Where the stop is

Nearest address NBT Bank Parkway, City of Syracuse, NY 13290 (© OpenStreetMap contributors)

In Syracuse, NY, at 43.07524, -76.16997. Open in Google Maps of Syracuse Regional Transportation Center (Google Maps) · Directions to Syracuse Regional Transportation Center (Google Maps)

Names the carriers use for it:

  • Syracuse
  • Syracuse Regional Transportation Center
  • Syracuse Bus Station
  • Syracuse, NY (Destiny USA Mall- Centro bus stop between Macys and former JC Penneys)

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Where you can go from here

Direct buses and trains from this stop. Pick a destination for its full timetable.

Direct destinations from Syracuse Regional Transportation Center
DestinationBuses and trains a weekFastestCompany
New York, NY117 buses and trains a weekFastest 4h 30mAdirondack Trailways, Amtrak, FlixBus and Greyhound
Rochester, NY116 buses and trains a weekFastest 1h 16mAdirondack Trailways, Amtrak, FlixBus and Greyhound
Buffalo, NY BUF airport109 buses and trains a weekFastest 2h 22mAdirondack Trailways, Amtrak, FlixBus and Greyhound
Binghamton, NY69 buses a weekFastest 1h 15mAdirondack Trailways, FlixBus and Greyhound
Albany, NY ALB airport65 buses and trains a weekFastest 2h 36mAdirondack Trailways, Amtrak, FlixBus and Greyhound
Utica, NY58 buses and trains a weekFastest 53mAdirondack Trailways, Amtrak, FlixBus and Greyhound
Schenectady, NY51 buses and trains a weekFastest 2h 15mAdirondack Trailways, Amtrak, FlixBus and Greyhound
Newark, NJ46 buses a weekFastest 4h 05mAdirondack Trailways, FlixBus and Greyhound
Niagara Falls, NY BUF airport40 buses and trains a weekFastest 3h 29mAmtrak and FlixBus
Batavia, NY35 buses a weekFastest 2h 15mAdirondack Trailways and Greyhound
Cortland, NY34 buses a weekFastest 35mAdirondack Trailways, Greyhound and OurBus
Amsterdam, NY34 buses and trains a weekFastest 1h 55mAdirondack Trailways, Amtrak and Greyhound
Rhinecliff, NY27 trains a weekFastest 3h 43mAmtrak
Poughkeepsie, NY27 trains a weekFastest 4h 04mAmtrak
Croton-on-Hudson, NY27 trains a weekFastest 4h 44mAmtrak
Springfield, MA24 buses and trains a weekFastest 4h 25mAmtrak, FlixBus and Greyhound
Boston, MA24 buses and trains a weekFastest 6h 25mAmtrak, FlixBus and Greyhound
Cleveland, OH21 buses and trains a weekFastest 5h 48mAmtrak and Greyhound
Rome, NY20 trains a weekFastest 38mAmtrak
Hudson, NY20 trains a weekFastest 3h 20mAmtrak
McGraw, NY15 buses a weekFastest 40mFlixBus
Pulaski, NY SYR airport14 buses a weekFastest 33mAdirondack Trailways
Watertown, NY SYR airport14 buses a weekFastest 1h 10mAdirondack Trailways
Evans Mills, NY SYR airport14 buses a weekFastest 1h 25mAdirondack Trailways
Philadelphia, NY SYR airport14 buses a weekFastest 1h 33mAdirondack Trailways
Gouverneur, NY SYR airport14 buses a weekFastest 1h 55mAdirondack Trailways
DeKalb Junction, NY SYR airport14 buses a weekFastest 2h 23mAdirondack Trailways
Canton, NY SYR airport14 buses a weekFastest 2h 33mAdirondack Trailways
Potsdam, NY SYR airport14 buses a weekFastest 2h 51mAdirondack Trailways
Toronto, ON BUF airport14 buses and trains a weekFastest 6h 15mAdirondack Trailways and Amtrak
Erie, PA14 trains a weekFastest 4h 05mAmtrak
Elyria, OH14 trains a weekFastest 6h 27mAmtrak
Sandusky, OH14 trains a weekFastest 7h 04mAmtrak
Toledo, OH14 trains a weekFastest 8h 08mAmtrak
Bryan, OH14 trains a weekFastest 9h 18mAmtrak
Waterloo, IN14 trains a weekFastest 9h 46mAmtrak
Elkhart, IN14 trains a weekFastest 10h 38mAmtrak
South Bend, IN14 trains a weekFastest 10h 59mAmtrak
Chicago, IL14 trains a weekFastest 13h 07mAmtrak
Scranton, PA14 buses a weekFastest 2h 15mFlixBus and Greyhound
Yonkers, NY13 trains a weekFastest 5h 12mAmtrak
Emerald Lakes, PA12 buses a weekFastest 2h 55mFlixBus
Ithaca, NY11 buses a weekFastest 1h 09mFlixBus and OurBus
Malone, NY7 buses a weekFastest 4h 10mAdirondack Trailways
Paul Smiths, NY7 buses a weekFastest 4h 45mAdirondack Trailways
Saranac Lake, NY7 buses a weekFastest 5h 00mAdirondack Trailways
Lake Placid, NY7 buses a weekFastest 5h 30mAdirondack Trailways
Schroon Lake, NY7 buses a weekFastest 6h 30mAdirondack Trailways
Pottersville, NY7 buses a weekFastest 6h 43mAdirondack Trailways
Chestertown, NY7 buses a weekFastest 6h 53mAdirondack Trailways
Warrensburg, NY7 buses a weekFastest 7h 07mAdirondack Trailways
Lake George, NY7 buses a weekFastest 7h 17mAdirondack Trailways
Glens Falls, NY7 buses a weekFastest 7h 40mAdirondack Trailways
Saratoga Springs, NY7 buses a weekFastest 8h 15mAdirondack Trailways
Massena, NY SYR airport7 buses a weekFastest 4h 05mAdirondack Trailways
Fort Plain, NY7 buses a weekFastest 1h 40mAdirondack Trailways
Pittsfield, MA7 trains a weekFastest 4h 48mAmtrak
Worcester, MA7 trains a weekFastest 7h 48mAmtrak
Framingham, MA7 trains a weekFastest 8h 16mAmtrak
Union City, NJ6 buses a weekFastest 4h 30mAdirondack Trailways
Middletown, NY3 buses a weekFastest 3h 25mAdirondack Trailways
Ridgewood, NJ3 buses a weekFastest 4h 10mAdirondack Trailways
Cayuga Heights, NY3 buses a weekFastest 1h 25mFlixBus

Departures

Every bus or train leaving this stop, by time of day. Times are local. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.

Departures from Syracuse Regional Transportation Center
DepartsGoing toDaysCompany
12:20 AMNew YorkDailyGreyhound
12:55 AMToronto BUF airportDailyAdirondack Trailways
1:15 AMNew YorkDailyFlixBus
1:30 AMBuffalo BUF airportDaily except WedFlixBus
2:30 AMNew YorkDaily except WedFlixBus
2:30 AMNiagara Falls BUF airportDailyFlixBus
2:35 AMNew YorkDailyAdirondack Trailways
3:55 AMNew YorkDailyGreyhound
4:30 AMBuffaloDailyGreyhound
6:30 AMNew YorkMon, Tue, Wed, Fri, SunAdirondack Trailways
6:45 AMAlbany ALB airportDailyAdirondack Trailways
6:50 AMBostonDailyGreyhound
7:00 AMBuffaloDailyGreyhound
7:02 AMNew YorkDailyAmtrak
7:06 AMNew YorkDaily from Nov 2Amtrak
7:30 AMNew YorkDailyGreyhound
8:00 AMAlbanyDailyAdirondack Trailways
8:35 AMNew YorkMon, Tue, Fri, Sat, SunFlixBus
9:25 AMNew YorkDailyGreyhound
9:45 AMNew YorkMon, Thu, Fri, Sat, SunAdirondack Trailways
9:55 AMNew YorkDailyAmtrak
9:59 AMNew YorkDaily from Nov 2Amtrak
10:00 AMRochesterDailyAdirondack Trailways
11:42 AMBostonDailyAmtrak
11:42 AMNew YorkDailyAmtrak
11:55 AMBuffaloDailyGreyhound
12:00 PMBostonDailyGreyhound
12:15 PMNew YorkDailyFlixBus
12:57 PMTorontoDaily from Nov 2Amtrak
12:59 PMTorontoDailyAmtrak
1:15 PMIthacaFri, SunOurBus
1:45 PMNiagara Falls BUF airportMon, Thu, Fri, Sat, SunFlixBus
2:20 PMBuffaloDailyGreyhound
2:25 PM NewRochesterSun from Nov 29Adirondack Trailways
2:50 PMNew YorkTue–SunAmtrak
2:51 PMNew YorkDaily from Nov 2Amtrak
3:05 PMNew YorkDailyAdirondack Trailways
3:25 PMBuffaloDailyAdirondack Trailways
3:30 PMMassena SYR airportDailyAdirondack Trailways
3:55 PMBostonTue, Fri, SunFlixBus
4:00 PMPotsdamSun from Nov 29Adirondack Trailways
4:02 PMNiagara FallsDaily from Nov 2Amtrak
4:09 PMNiagara FallsDailyAmtrak
5:00 PMNew YorkFriAdirondack Trailways
5:30 PMNiagara Falls BUF airportDailyFlixBus
6:40 PMIthacaDaily except SatOurBus
6:59 PMNiagara FallsDaily from Nov 2Amtrak
7:01 PMNiagara FallsDailyAmtrak
7:20 PMNew YorkDailyGreyhound
7:35 PM NewRochesterSun from Nov 29Adirondack Trailways
7:35 PMClevelandDailyGreyhound
8:05 PM NewRochesterSun from Nov 29Adirondack Trailways
8:35 PM NewRochesterSun from Nov 29Adirondack Trailways
9:00 PMNew YorkDailyGreyhound
10:05 PMChicagoDailyAmtrak
10:05 PMChicagoDailyAmtrak
10:50 PMCayuga HeightsMon, Thu, SatFlixBus

Buses and trains arriving from

Questions

Which bus and rail companies stop at Syracuse Regional Transportation Center?

Adirondack Trailways, Amtrak, FlixBus, Greyhound and OurBus stop at Syracuse Regional Transportation Center in Syracuse, NY.

What time does the first departure leave Syracuse Regional Transportation Center?

The first departure is at 12:20 AM (Daily) and the last at 10:50 PM (Mon, Thu, Sat). Times are local.

Where can I go from Syracuse Regional Transportation Center?

Direct buses and trains go to 63 cities and towns, including New York, Rochester, Buffalo, Binghamton and Albany.

Where is Syracuse Regional Transportation Center?

Syracuse Regional Transportation Center is in Syracuse, NY, at NBT Bank Parkway, City of Syracuse, NY 13290 (the nearest address on OpenStreetMap), at latitude 43.07524, longitude -76.16997. Carriers also list it as Syracuse, Syracuse Bus Station and Syracuse, NY (Destiny USA Mall- Centro bus stop between Macys and former JC Penneys).

Other stops in Syracuse

All Syracuse schedules