NY → NY · about 135 miles
Syracuse to Buffalo bus & train schedule
Adirondack Trailways, Amtrak, FlixBus, Greyhound and OurBus run 109 direct buses and trains a week from Syracuse to Buffalo. The fastest takes 2 hours 22 minutes; the first departure leaves at 12:55 AM and the last at 10:05 PM.
Timetable data from · Schedule last changed
- Buses and trains a week
- 109
- Fastest trip
- 2h 22m
- First departure
- 12:55 AM
- Last departure
- 10:05 PM
32 of the 109 buses and trains a week stop at Buffalo Niagara International Airport (BUF).
Timetable
Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Stops | Company | Ticket |
|---|---|---|---|---|---|---|
| 12:55 AM | 3:45 AM | 2h 50m | Daily | Syracuse to Buffalo (Airport) | Adirondack Trailways Full timetable | Book (carrier website) |
| 1:30 AM | 4:40 AM | 3h 10m | Daily except Wed | Syracuse Bus Station to Buffalo International Airport Buffalo Niagara | FlixBus Full timetable | No online booking link |
| 2:30 AM | 5:15 AM | 2h 45m | Daily | Syracuse Bus Station to Buffalo International Airport Buffalo Niagara | FlixBus Full timetable | No online booking link |
| 2:35 AM | 5:25 AM | 2h 50m | Mon from Nov 30 | Syracuse, NY (Syracuse University- Waverly Ave. between Walnut Place and University Ave.) to Buffalo, NY (SUNY Buffalo North Campus area - Maple Road Sunoco station at 4641 Maple Road) | OurBus Full timetable | No online booking link |
| 4:30 AM | 7:30 AM | 3h 00m | Daily | Syracuse Bus Station to Buffalo | Greyhound Full timetable | No online booking link |
| 7:00 AM | 10:20 AM | 3h 20m | Daily | Syracuse Bus Station to Buffalo | Greyhound Full timetable | No online booking link |
| 11:55 AM | 3:05 PM | 3h 10m | Daily | Syracuse Bus Station to Buffalo | Greyhound Full timetable | No online booking link |
| 12:57 PM | 3:19 PM | 2h 22m | Daily from Nov 2 | Syracuse Regional Transportation Center to Buffalo Depew Station | Amtrak Full timetable | No online booking link |
| 12:59 PM | 3:25 PM | 2h 26m | Daily | Syracuse Regional Transportation Center to Buffalo Depew Station | Amtrak Full timetable | No online booking link |
| 1:45 PM | 4:40 PM | 2h 55m | Mon, Thu, Fri, Sat, Sun | Syracuse Bus Station to Buffalo International Airport Buffalo Niagara | FlixBus Full timetable | No online booking link |
| 2:10 PM | 5:00 PM | 2h 50m | Daily from Nov 20 | Syracuse, NY (Syracuse University- Waverly Ave. between Walnut Place and University Ave.) to Buffalo, NY (Buffalo Niagara International Airport - bus parking area. From the main terminal arrivals level, follow signs for buses and ride share. Bus will stop at the area with Authorized Charter Coach Bus Pickup signs) | OurBus Full timetable | No online booking link |
| 2:20 PM | 5:25 PM | 3h 05m | Daily | Syracuse Bus Station to Buffalo | Greyhound Full timetable | No online booking link |
| 3:25 PM | 6:30 PM | 3h 05m | Daily | Syracuse to Buffalo | Adirondack Trailways Full timetable | Book (carrier website) |
| 4:02 PM | 6:34 PM | 2h 32m | Daily from Nov 2 | Syracuse Regional Transportation Center to Buffalo Depew Station | Amtrak Full timetable | No online booking link |
| 4:09 PM | 6:40 PM | 2h 31m | Daily | Syracuse Regional Transportation Center to Buffalo Depew Station | Amtrak Full timetable | No online booking link |
| 5:30 PM | 8:15 PM | 2h 45m | Daily | Syracuse Bus Station to Buffalo International Airport Buffalo Niagara | FlixBus Full timetable | No online booking link |
| 6:59 PM | 9:21 PM | 2h 22m | Daily from Nov 2 | Syracuse Regional Transportation Center to Buffalo Depew Station | Amtrak Full timetable | No online booking link |
| 7:01 PM | 9:27 PM | 2h 26m | Daily | Syracuse Regional Transportation Center to Buffalo Depew Station | Amtrak Full timetable | No online booking link |
| 7:35 PM | 10:35 PM | 3h 00m | Daily | Syracuse Bus Station to Buffalo | Greyhound Full timetable | No online booking link |
| 10:05 PM | 12:29 AM +1 day | 2h 24m | Daily | Syracuse Regional Transportation Center to Buffalo Depew Station | Amtrak Full timetable | No online booking link |
Route map
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Where to board in Syracuse Where you get off in Buffalo The route of the busiest trip
Where to board in Syracuse
Where buses and trains stop in Buffalo
Return trip: Buffalo to Syracuse
Questions
How long is the bus or train from Syracuse to Buffalo?
The fastest direct bus or train takes 2 hours 22 minutes; the typical trip is 2 hours 45 minutes.
What time is the first departure from Syracuse to Buffalo?
The earliest departure is at 12:55 AM (Daily) and the last at 10:05 PM (Daily).
Which bus and rail companies go from Syracuse to Buffalo?
Adirondack Trailways, Amtrak, FlixBus, Greyhound and OurBus run direct buses and trains on this route.
Where do I board in Syracuse?
Buses and trains to Buffalo leave from Syracuse Regional Transportation Center and Syracuse (Syr Univ).
Does the bus or train from Syracuse to Buffalo stop at Buffalo Niagara International Airport?
Yes, 32 of the 109 a week: at Buffalo (Airport).