FL → SC · about 406 miles
Orlando to Florence bus & train schedule
Amtrak and FlixBus run 12 direct buses and trains a week from Orlando to Florence. The fastest takes 8 hours 25 minutes; the first departure leaves at 12:36 PM and the last at 3:40 PM.
Timetable data from · No schedule changes since at least
- Buses and trains a week
- 12
- Fastest trip
- 8h 25m
- First departure
- 12:36 PM
- Last departure
- 3:40 PM
Timetable
Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Stops | Company |
|---|---|---|---|---|---|
| 12:36 PM | 10:22 PM | 9h 46m | Daily | Orlando to Florence Amtrak Station | Amtrak Full timetable |
| 3:40 PM | 12:05 AM +1 day | 8h 25m | Mon, Thu, Fri, Sat, Sun | Orlando Bus Station to Florence Sc | FlixBus Full timetable |
Route map
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Where to board in Orlando Where you get off in Florence The route of the busiest trip
Where to board in Orlando
Where buses and trains stop in Florence
Return trip: Florence to Orlando
Questions
How long is the bus or train from Orlando to Florence?
The fastest direct bus or train takes 8 hours 25 minutes; the typical trip is 9 hours 46 minutes.
What time is the first departure from Orlando to Florence?
The earliest departure is at 12:36 PM (Daily except Sat) and the last at 3:40 PM (Mon, Thu, Fri, Sat, Sun).
Which bus and rail companies go from Orlando to Florence?
Amtrak and FlixBus run direct buses and trains on this route.
Where do I board in Orlando?
Buses and trains to Florence leave from Orlando Amtrak station and Orlando Bus Station.