DC → SC · about 358 miles
Washington to Florence bus & train schedule
Amtrak and FlixBus run 19 direct buses and trains a week from Washington to Florence. The fastest takes 7 hours 46 minutes; the first departure leaves at 12:55 PM and the last at 9:45 PM.
Timetable data from · No schedule changes since at least
- Buses and trains a week
- 19
- Fastest trip
- 7h 46m
- First departure
- 12:55 PM
- Last departure
- 9:45 PM
Timetable
Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Stops | Company |
|---|---|---|---|---|---|
| 12:55 PM | 8:43 PM | 7h 48m | Daily | Washington Union Station to Florence Amtrak Station | Amtrak Full timetable |
| 7:24 PM | 3:10 AM +1 day | 7h 46m | Daily | Washington Union Station to Florence Amtrak Station | Amtrak Full timetable |
| 9:45 PM | 5:45 AM +1 day | 8h 00m | Wed–Sun | Washington DC Bus Station to Florence Sc | FlixBus Full timetable |
Route map
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Where to board in Washington Where you get off in Florence The route of the busiest trip
Where to board in Washington
Where buses and trains stop in Florence
Return trip: Florence to Washington
Questions
How long is the bus or train from Washington to Florence?
The fastest direct bus or train takes 7 hours 46 minutes; the typical trip is 7 hours 48 minutes.
What time is the first departure from Washington to Florence?
The earliest departure is at 12:55 PM (Daily) and the last at 9:45 PM (Wed–Sun).
Which bus and rail companies go from Washington to Florence?
Amtrak and FlixBus run direct buses and trains on this route.
Where do I board in Washington?
Buses and trains to Florence leave from Washington (Union Station).