MD → SC · about 391 miles
Baltimore to Florence bus & train schedule
Amtrak and FlixBus run 19 direct buses and trains a week from Baltimore to Florence. The fastest takes 9 hours 15 minutes; the first departure leaves at 8:48 AM and the last at 8:30 PM.
Timetable data from · No schedule changes since at least
- Buses and trains a week
- 19
- Fastest trip
- 9h 15m
- First departure
- 8:48 AM
- Last departure
- 8:30 PM
Timetable
Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Stops | Company |
|---|---|---|---|---|---|
| 8:48 AM | 8:43 PM | 11h 55m | Daily from Dec 19 | Baltimore Penn Station to Florence Amtrak Station | Amtrak Full timetable |
| 8:51 AM | 8:43 PM | 11h 52m | Daily | Baltimore Penn Station to Florence Amtrak Station | Amtrak Full timetable |
| 5:32 PM | 3:10 AM +1 day | 9h 38m | Daily from Dec 19 | Baltimore Penn Station to Florence Amtrak Station | Amtrak Full timetable |
| 5:38 PM | 3:10 AM +1 day | 9h 32m | Daily | Baltimore Penn Station to Florence Amtrak Station | Amtrak Full timetable |
| 8:30 PM | 5:45 AM +1 day | 9h 15m | Wed–Sun | Baltimore Downtown Bus Station to Florence Sc | FlixBus Full timetable |
Route map
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Where to board in Baltimore Where you get off in Florence The route of the busiest trip
Where to board in Baltimore
Where buses and trains stop in Florence
Return trip: Florence to Baltimore
Questions
How long is the bus or train from Baltimore to Florence?
The fastest direct bus or train takes 9 hours 15 minutes; the typical trip is 9 hours 38 minutes.
What time is the first departure from Baltimore to Florence?
The earliest departure is at 8:48 AM (Daily) and the last at 8:30 PM (Wed–Sun).
Which bus and rail companies go from Baltimore to Florence?
Amtrak and FlixBus run direct buses and trains on this route.
Where do I board in Baltimore?
Buses and trains to Florence leave from Baltimore Penn Station and Baltimore (Downtown).