SC → MD · about 391 miles
Florence to Baltimore bus & train schedule
Amtrak and FlixBus run 18 direct buses and trains a week from Florence to Baltimore. The fastest takes 9 hours 3 minutes; the first departure leaves at 12:05 AM and the last at 10:32 PM.
Timetable data from · Schedule last changed
- Buses and trains a week
- 18
- Fastest trip
- 9h 03m
- First departure
- 12:05 AM
- Last departure
- 10:32 PM
Timetable
Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Stops | Company |
|---|---|---|---|---|---|
| 12:05 AM | 9:25 AM | 9h 20m | Mon, Tue, Fri, Sat, Sun | Florence Sc to Baltimore Downtown Bus Station | FlixBus Full timetable |
| 10:54 AM | 8:31 PM | 9h 37m | Fri–Sun from Nov 6 | Florence Amtrak Station to Baltimore Penn Station | Amtrak Full timetable |
| 10:54 AM | 8:38 PM | 9h 44m | Daily | Florence Amtrak Station to Baltimore Penn Station | Amtrak Full timetable |
| 10:32 PM | 7:35 AM +1 day | 9h 03m | Sat from Nov 7 | Florence Amtrak Station to Baltimore Penn Station | Amtrak Full timetable |
| 10:32 PM | 7:40 AM +1 day | 9h 08m | Sat | Florence Amtrak Station to Baltimore Penn Station | Amtrak Full timetable |
| 10:32 PM | 7:48 AM +1 day | 9h 16m | Fri from Nov 6 | Florence Amtrak Station to Baltimore Penn Station | Amtrak Full timetable |
| 10:32 PM | 7:50 AM +1 day | 9h 18m | Fri, Sat from Nov 21 | Florence Amtrak Station to Baltimore Penn Station | Amtrak Full timetable |
| 10:32 PM | 8:07 AM +1 day | 9h 35m | Daily except Sat | Florence Amtrak Station to Baltimore Penn Station | Amtrak Full timetable |
Route map
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Where to board in Florence Where you get off in Baltimore The route of the busiest trip
Where to board in Florence
Where buses and trains stop in Baltimore
Return trip: Baltimore to Florence
Questions
How long is the bus or train from Florence to Baltimore?
The fastest direct bus or train takes 9 hours 3 minutes; the typical trip is 9 hours 35 minutes.
What time is the first departure from Florence to Baltimore?
The earliest departure is at 12:05 AM (Mon, Tue, Fri, Sat, Sun) and the last at 10:32 PM (Daily except Sat).
Which bus and rail companies go from Florence to Baltimore?
Amtrak and FlixBus run direct buses and trains on this route.
Where do I board in Florence?
Buses and trains to Baltimore leave from Florence Amtrak Station and Florence FlixBus bus stop.