SC → FL · about 406 miles
Florence to Orlando bus & train schedule
Amtrak and FlixBus run 12 direct buses and trains a week from Florence to Orlando. The fastest takes 8 hours 25 minutes; the first departure leaves at 3:18 AM and the last at 5:45 AM.
Timetable data from · No schedule changes since at least
- Buses and trains a week
- 12
- Fastest trip
- 8h 25m
- First departure
- 3:18 AM
- Last departure
- 5:45 AM
Timetable
Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Stops | Company |
|---|---|---|---|---|---|
| 3:18 AM | 1:04 PM | 9h 46m | Daily | Florence Amtrak Station to Orlando | Amtrak Full timetable |
| 5:45 AM | 2:10 PM | 8h 25m | Mon, Thu, Fri, Sat, Sun | Florence Sc to Orlando Bus Station | FlixBus Full timetable |
Route map
The map needs JavaScript.
Where to board in Florence Where you get off in Orlando The route of the busiest trip
Where to board in Florence
Where buses and trains stop in Orlando
Return trip: Orlando to Florence
Questions
How long is the bus or train from Florence to Orlando?
The fastest direct bus or train takes 8 hours 25 minutes; the typical trip is 9 hours 46 minutes.
What time is the first departure from Florence to Orlando?
The earliest departure is at 3:18 AM (Daily) and the last at 5:45 AM (Mon, Thu, Fri, Sat, Sun).
Which bus and rail companies go from Florence to Orlando?
Amtrak and FlixBus run direct buses and trains on this route.
Where do I board in Florence?
Buses and trains to Orlando leave from Florence Amtrak Station and Florence FlixBus bus stop.