KY → IL · about 269 miles
Louisville to Chicago bus schedule
Greyhound runs 28 direct buses a week from Louisville to Chicago. The fastest takes 6 hours; the first bus leaves at 3:00 AM and the last at 2:45 PM.
Timetable data from · Schedule last changed
- Buses a week
- 28
- Fastest trip
- 6h 00m
- First bus
- 3:00 AM
- Last bus
- 2:45 PM
Timetable
Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Stops | Bus company |
|---|---|---|---|---|---|
| 3:00 AM | 8:00 AM | 6h 00m | Daily | Louisville Bus Station to Chicago Train Station | Greyhound Full timetable |
| 7:35 AM | 1:15 PM | 6h 40m | Daily | Louisville Bus Station to Chicago 95th / Dan Ryan | Greyhound Full timetable |
| 10:15 AM | 3:15 PM | 6h 00m | Daily | Louisville Bus Station to Chicago Bus Station | Greyhound Full timetable |
| 2:45 PM | 8:10 PM | 6h 25m | Daily | Louisville Bus Station to Chicago Bus Station | Greyhound Full timetable |
Route map
The map needs JavaScript.
Where to board in Louisville Where you get off in Chicago The route of the busiest trip
Where to catch the bus in Louisville
- Louisville Bus Station Map of Louisville Bus Station (Google Maps)
Where the bus stops in Chicago
Return trip: Chicago to Louisville
Questions
How long is the bus from Louisville to Chicago?
The fastest direct bus takes 6 hours; the typical trip is 6 hours 25 minutes.
What time is the first bus from Louisville to Chicago?
The earliest departure is at 3:00 AM (Daily) and the last at 2:45 PM (Daily).
Which bus companies go from Louisville to Chicago?
Greyhound runs direct buses on this route.
Where do I catch the bus in Louisville?
Buses to Chicago leave from Louisville Bus Station.