IL → KY · about 269 miles
Chicago to Louisville bus schedule
Greyhound runs 28 direct buses a week from Chicago to Louisville. The fastest takes 6 hours 5 minutes; the first bus leaves at 6:10 AM and the last at 10:50 PM.
Timetable data from · Schedule last changed
- Buses a week
- 28
- Fastest trip
- 6h 05m
- First bus
- 6:10 AM
- Last bus
- 10:50 PM
Timetable
Every bus leaves from Chicago Bus Station and arrives at Louisville Bus Station. Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company |
|---|---|---|---|---|
| 6:10 AM | 1:15 PM | 6h 05m | Daily | Greyhound Full timetable |
| 9:55 AM | 6:00 PM | 7h 05m | Daily | Greyhound Full timetable |
| 2:45 PM | 10:00 PM | 6h 15m | Daily | Greyhound Full timetable |
| 10:50 PM | 6:45 AM +1 day | 6h 55m | Daily | Greyhound Full timetable |
Route map
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Where to board in Chicago Where you get off in Louisville The route of the busiest trip
Where to catch the bus in Chicago
Where the bus stops in Louisville
- Louisville Bus Station Map of Louisville Bus Station (Google Maps)
Return trip: Louisville to Chicago
Questions
How long is the bus from Chicago to Louisville?
The fastest direct bus takes 6 hours 5 minutes; the typical trip is 6 hours 55 minutes.
What time is the first bus from Chicago to Louisville?
The earliest departure is at 6:10 AM (Daily) and the last at 10:50 PM (Daily).
Which bus companies go from Chicago to Louisville?
Greyhound runs direct buses on this route.
Where do I catch the bus in Chicago?
Buses to Louisville leave from Chicago Bus Station.