TN → KY · about 191 miles
Manchester to Louisville bus schedule
Greyhound runs 28 direct buses a week from Manchester to Louisville. The fastest takes 5 hours 20 minutes; the first bus leaves at 12:20 AM and the last at 7:20 PM.
Timetable data from · No schedule changes since at least
- Buses a week
- 28
- Fastest trip
- 5h 20m
- First bus
- 12:20 AM
- Last bus
- 7:20 PM
Timetable
Every bus leaves from Manchester Shell and arrives at Louisville Bus Station. Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company |
|---|---|---|---|---|
| 12:20 AM | 7:00 AM | 5h 40m | Daily | Greyhound Full timetable |
| 3:10 AM | 9:40 AM | 5h 30m | Daily | Greyhound Full timetable |
| 7:40 AM | 2:25 PM | 5h 45m | Daily | Greyhound Full timetable |
| 7:20 PM | 1:40 AM +1 day | 5h 20m | Daily | Greyhound Full timetable |
Route map
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Where to board in Manchester Where you get off in Louisville The route of the busiest trip
Where to catch the bus in Manchester
- Manchester Shell Map of Manchester Shell (Google Maps)
Where the bus stops in Louisville
- Louisville Bus Station Map of Louisville Bus Station (Google Maps)
Return trip: Louisville to Manchester
Questions
How long is the bus from Manchester to Louisville?
The fastest direct bus takes 5 hours 20 minutes; the typical trip is 5 hours 40 minutes.
What time is the first bus from Manchester to Louisville?
The earliest departure is at 12:20 AM (Daily) and the last at 7:20 PM (Daily).
Which bus companies go from Manchester to Louisville?
Greyhound runs direct buses on this route.
Where do I catch the bus in Manchester?
Buses to Louisville leave from Manchester Shell.