FL → SC · about 290 miles
Jacksonville to Florence bus & train schedule
Amtrak and FlixBus run 12 direct buses and trains a week from Jacksonville to Florence. The fastest takes 5 hours 35 minutes; the first departure leaves at 4:11 PM and the last at 6:30 PM.
Timetable data from · No schedule changes since at least
- Buses and trains a week
- 12
- Fastest trip
- 5h 35m
- First departure
- 4:11 PM
- Last departure
- 6:30 PM
Timetable
Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Stops | Company |
|---|---|---|---|---|---|
| 4:11 PM | 10:22 PM | 6h 11m | Daily | Jacksonville to Florence Amtrak Station | Amtrak Full timetable |
| 6:30 PM | 12:05 AM +1 day | 5h 35m | Mon, Thu, Fri, Sat, Sun | Jacksonville Greyhound Bus Station to Florence Sc | FlixBus Full timetable |
Route map
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Where to board in Jacksonville Where you get off in Florence The route of the busiest trip
Where to board in Jacksonville
Where buses and trains stop in Florence
Return trip: Florence to Jacksonville
Questions
How long is the bus or train from Jacksonville to Florence?
The fastest direct bus or train takes 5 hours 35 minutes; the typical trip is 6 hours 11 minutes.
What time is the first departure from Jacksonville to Florence?
The earliest departure is at 4:11 PM (Daily except Sat) and the last at 6:30 PM (Mon, Thu, Fri, Sat, Sun).
Which bus and rail companies go from Jacksonville to Florence?
Amtrak and FlixBus run direct buses and trains on this route.
Where do I board in Jacksonville?
Buses and trains to Florence leave from Jacksonville Amtrak station and Jacksonville Greyhound Bus Station.