SC → FL · about 290 miles
Florence to Jacksonville bus & train schedule
Amtrak and FlixBus run 12 direct buses and trains a week from Florence to Jacksonville. The fastest takes 5 hours 45 minutes; the first departure leaves at 3:18 AM and the last at 5:45 AM.
Timetable data from · No schedule changes since at least
- Buses and trains a week
- 12
- Fastest trip
- 5h 45m
- First departure
- 3:18 AM
- Last departure
- 5:45 AM
Timetable
Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Stops | Company |
|---|---|---|---|---|---|
| 3:18 AM | 9:24 AM | 6h 06m | Daily | Florence Amtrak Station to Jacksonville | Amtrak Full timetable |
| 5:45 AM | 11:30 AM | 5h 45m | Mon, Thu, Fri, Sat, Sun | Florence Sc to Jacksonville Greyhound Bus Station | FlixBus Full timetable |
Route map
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Where to board in Florence Where you get off in Jacksonville The route of the busiest trip
Where to board in Florence
Where buses and trains stop in Jacksonville
Return trip: Jacksonville to Florence
Questions
How long is the bus or train from Florence to Jacksonville?
The fastest direct bus or train takes 5 hours 45 minutes; the typical trip is 6 hours 6 minutes.
What time is the first departure from Florence to Jacksonville?
The earliest departure is at 3:18 AM (Daily) and the last at 5:45 AM (Mon, Thu, Fri, Sat, Sun).
Which bus and rail companies go from Florence to Jacksonville?
Amtrak and FlixBus run direct buses and trains on this route.
Where do I board in Florence?
Buses and trains to Jacksonville leave from Florence Amtrak Station and Florence FlixBus bus stop.