IN → MO · about 229 miles
Indianapolis to St. Louis bus schedule
Greyhound runs 14 direct buses a week from Indianapolis to St. Louis. The fastest takes 3 hours 55 minutes; the first bus leaves at 5:00 AM and the last at 11:05 AM.
Timetable data from · No schedule changes since at least
- Buses a week
- 14
- Fastest trip
- 3h 55m
- First bus
- 5:00 AM
- Last bus
- 11:05 AM
Timetable
Every bus leaves from Indianapolis Bus Station and arrives at St Louis Bus Station. Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company |
|---|---|---|---|---|
| 5:00 AM | 7:55 AM | 3h 55m | Daily | Greyhound Full timetable |
| 11:05 AM | 3:10 PM | 5h 05m | Daily | Greyhound Full timetable |
Route map
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Where to board in Indianapolis Where you get off in St. Louis The route of the busiest trip
Where to catch the bus in Indianapolis
Where the bus stops in St. Louis
- St Louis Bus Station Map of St Louis Bus Station (Google Maps)
Return trip: St. Louis to Indianapolis
Questions
How long is the bus from Indianapolis to St. Louis?
The fastest direct bus takes 3 hours 55 minutes.
What time is the first bus from Indianapolis to St. Louis?
The earliest departure is at 5:00 AM (Daily) and the last at 11:05 AM (Daily).
Which bus companies go from Indianapolis to St. Louis?
Greyhound runs direct buses on this route.
Where do I catch the bus in Indianapolis?
Buses to St. Louis leave from Indianapolis Bus Station.