IL → MO · about 261 miles
Chicago to St. Louis bus & train schedule
Amtrak and FlixBus run 53 direct buses and trains a week from Chicago to St. Louis. The fastest takes 4 hours 46 minutes; the first departure leaves at 12:15 AM and the last at 7:10 PM.
Timetable data from · Schedule last changed
- Buses and trains a week
- 53
- Fastest trip
- 4h 46m
- First departure
- 12:15 AM
- Last departure
- 7:10 PM
Timetable
Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Stops | Company |
|---|---|---|---|---|---|
| 12:15 AM | 6:20 AM | 6h 05m | Mon, Thu, Fri, Sat, Sun | Chicago Bus Station to St Louis Bus Station | FlixBus Full timetable |
| 7:15 AM | 12:01 PM | 4h 46m | Daily | Chicago Union Station to St. Louis | Amtrak Full timetable |
| 9:45 AM | 3:40 PM | 5h 55m | Mon, Thu, Fri, Sat, Sun | Chicago Bus Station to St Louis Bus Station | FlixBus Full timetable |
| 9:50 AM | 2:51 PM | 5h 01m | Daily | Chicago Union Station to St. Louis | Amtrak Full timetable |
| 2:10 PM | 7:25 PM | 5h 15m | Daily | Chicago Union Station to St. Louis | Amtrak Full timetable |
| 5:05 PM | 11:20 PM | 6h 15m | Mon, Thu, Fri, Sat, Sun | Chicago Bus Station to St Louis Bus Station | FlixBus Full timetable |
| 5:20 PM | 10:23 PM | 5h 03m | Daily | Chicago Union Station to St. Louis | Amtrak Full timetable |
| 7:10 PM | 12:09 AM +1 day | 4h 59m | Daily | Chicago Union Station to St. Louis | Amtrak Full timetable |
Route map
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Where to board in Chicago Where you get off in St. Louis The route of the busiest trip
Where to board in Chicago
Where buses and trains stop in St. Louis
- St Louis Bus Station Map of St Louis Bus Station (Google Maps)
Return trip: St. Louis to Chicago
Questions
How long is the bus or train from Chicago to St. Louis?
The fastest direct bus or train takes 4 hours 46 minutes; the typical trip is 5 hours 15 minutes.
What time is the first departure from Chicago to St. Louis?
The earliest departure is at 12:15 AM (Mon, Thu, Fri, Sat, Sun) and the last at 7:10 PM (Daily).
Which bus and rail companies go from Chicago to St. Louis?
Amtrak and FlixBus run direct buses and trains on this route.
Where do I board in Chicago?
Buses and trains to St. Louis leave from Chicago Union Station and Chicago Bus Station.