MO → IL · about 261 miles
St. Louis to Chicago bus & train schedule
Amtrak and FlixBus run 53 direct buses and trains a week from St. Louis to Chicago. The fastest takes 4 hours 55 minutes; the first departure leaves at 4:30 AM and the last at 11:30 PM.
Timetable data from · Schedule last changed
- Buses and trains a week
- 53
- Fastest trip
- 4h 55m
- First departure
- 4:30 AM
- Last departure
- 11:30 PM
Timetable
Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Stops | Company |
|---|---|---|---|---|---|
| 4:30 AM | 9:25 AM | 4h 55m | Daily | St. Louis to Chicago Union Station | Amtrak Full timetable |
| 6:35 AM | 11:40 AM | 5h 05m | Daily | St. Louis to Chicago Union Station | Amtrak Full timetable |
| 8:10 AM | 1:49 PM | 5h 39m | Daily | St. Louis to Chicago Union Station | Amtrak Full timetable |
| 10:00 AM | 4:05 PM | 6h 05m | Mon, Tue, Fri, Sat, Sun | St Louis Bus Station to Chicago Bus Station | FlixBus Full timetable |
| 2:30 PM | 8:35 PM | 6h 05m | Mon, Tue, Fri, Sat, Sun | St Louis Bus Station to Chicago Bus Station | FlixBus Full timetable |
| 2:55 PM | 8:00 PM | 5h 05m | Daily | St. Louis to Chicago Union Station | Amtrak Full timetable |
| 5:40 PM | 10:43 PM | 5h 03m | Daily | St. Louis to Chicago Union Station | Amtrak Full timetable |
| 11:30 PM | 5:10 AM +1 day | 5h 40m | Mon, Thu, Fri, Sat, Sun | St Louis Bus Station to Chicago 95th / Dan Ryan | FlixBus Full timetable |
Route map
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Where to board in St. Louis Where you get off in Chicago The route of the busiest trip
Where to board in St. Louis
- St Louis Bus Station Map of St Louis Bus Station (Google Maps)
Where buses and trains stop in Chicago
Return trip: Chicago to St. Louis
Questions
How long is the bus or train from St. Louis to Chicago?
The fastest direct bus or train takes 4 hours 55 minutes; the typical trip is 5 hours 39 minutes.
What time is the first departure from St. Louis to Chicago?
The earliest departure is at 4:30 AM (Daily) and the last at 11:30 PM (Mon, Thu, Fri, Sat, Sun).
Which bus and rail companies go from St. Louis to Chicago?
Amtrak and FlixBus run direct buses and trains on this route.
Where do I board in St. Louis?
Buses and trains to Chicago leave from St Louis Bus Station.