MO → IN · about 229 miles
St. Louis to Indianapolis bus schedule
Greyhound runs 21 direct buses a week from St. Louis to Indianapolis. The fastest takes 4 hours 25 minutes; the first bus leaves at 2:00 AM and the last at 2:05 PM.
Timetable data from · No schedule changes since at least
- Buses a week
- 21
- Fastest trip
- 4h 25m
- First bus
- 2:00 AM
- Last bus
- 2:05 PM
Timetable
Every bus leaves from St Louis Bus Station and arrives at Indianapolis Bus Station. Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company |
|---|---|---|---|---|
| 2:00 AM | 7:25 AM | 4h 25m | Daily | Greyhound Full timetable |
| 8:45 AM | 2:30 PM | 4h 45m | Daily | Greyhound Full timetable |
| 2:05 PM | 7:30 PM | 4h 25m | Daily | Greyhound Full timetable |
Route map
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Where to board in St. Louis Where you get off in Indianapolis The route of the busiest trip
Where to catch the bus in St. Louis
- St Louis Bus Station Map of St Louis Bus Station (Google Maps)
Where the bus stops in Indianapolis
Return trip: Indianapolis to St. Louis
Questions
How long is the bus from St. Louis to Indianapolis?
The fastest direct bus takes 4 hours 25 minutes; the typical trip is 4 hours 25 minutes.
What time is the first bus from St. Louis to Indianapolis?
The earliest departure is at 2:00 AM (Daily) and the last at 2:05 PM (Daily).
Which bus companies go from St. Louis to Indianapolis?
Greyhound runs direct buses on this route.
Where do I catch the bus in St. Louis?
Buses to Indianapolis leave from St Louis Bus Station.