OH → MO · about 395 miles
Columbus to St. Louis bus schedule
Greyhound runs 14 direct buses a week from Columbus to St. Louis. The fastest takes 9 hours 5 minutes; the first bus leaves at 4:40 AM and the last at 11:50 PM.
Timetable data from · No schedule changes since at least
- Buses a week
- 14
- Fastest trip
- 9h 05m
- First bus
- 4:40 AM
- Last bus
- 11:50 PM
Timetable
Every bus leaves from Columbus E Mound St and arrives at St Louis Bus Station. Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company |
|---|---|---|---|---|
| 4:40 AM | 3:10 PM | 11h 30m | Daily | Greyhound Full timetable |
| 11:50 PM | 7:55 AM +1 day | 9h 05m | Daily | Greyhound Full timetable |
Route map
The map needs JavaScript.
Where to board in Columbus Where you get off in St. Louis The route of the busiest trip
Where to catch the bus in Columbus
Where the bus stops in St. Louis
- St Louis Bus Station Map of St Louis Bus Station (Google Maps)
Return trip: St. Louis to Columbus
Questions
How long is the bus from Columbus to St. Louis?
The fastest direct bus takes 9 hours 5 minutes.
What time is the first bus from Columbus to St. Louis?
The earliest departure is at 4:40 AM (Daily) and the last at 11:50 PM (Daily).
Which bus companies go from Columbus to St. Louis?
Greyhound runs direct buses on this route.
Where do I catch the bus in Columbus?
Buses to St. Louis leave from Columbus (E Mound St).