MO → OH · about 395 miles
St. Louis to Columbus bus schedule
Greyhound runs 21 direct buses a week from St. Louis to Columbus. The fastest takes 9 hours 40 minutes; the first bus leaves at 2:00 AM and the last at 2:05 PM.
Timetable data from · No schedule changes since at least
- Buses a week
- 21
- Fastest trip
- 9h 40m
- First bus
- 2:00 AM
- Last bus
- 2:05 PM
Timetable
Every bus leaves from St Louis Bus Station and arrives at Columbus E Mound St. Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company |
|---|---|---|---|---|
| 2:00 AM | 1:55 PM | 10h 55m | Daily | Greyhound Full timetable |
| 8:45 AM | 8:40 PM | 10h 55m | Daily | Greyhound Full timetable |
| 2:05 PM | 12:45 AM +1 day | 9h 40m | Daily | Greyhound Full timetable |
Route map
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Where to board in St. Louis Where you get off in Columbus The route of the busiest trip
Where to catch the bus in St. Louis
- St Louis Bus Station Map of St Louis Bus Station (Google Maps)
Where the bus stops in Columbus
Return trip: Columbus to St. Louis
Questions
How long is the bus from St. Louis to Columbus?
The fastest direct bus takes 9 hours 40 minutes; the typical trip is 10 hours 55 minutes.
What time is the first bus from St. Louis to Columbus?
The earliest departure is at 2:00 AM (Daily) and the last at 2:05 PM (Daily).
Which bus companies go from St. Louis to Columbus?
Greyhound runs direct buses on this route.
Where do I catch the bus in St. Louis?
Buses to Columbus leave from St Louis Bus Station.