WV → MO · about 516 miles
Wheeling to St. Louis bus schedule
Greyhound runs 7 direct buses a week from Wheeling to St. Louis. The fastest takes 11 hours 40 minutes; every bus leaves at 9:15 PM.
Timetable data from · No schedule changes since at least
- Buses a week
- 7
- Fastest trip
- 11h 40m
- Leaves at
- 9:15 PM
Timetable
Every bus leaves from Wheeling Bus Stop and arrives at St Louis Bus Station. Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company |
|---|---|---|---|---|
| 9:15 PM | 7:55 AM +1 day | 11h 40m | Daily | Greyhound Full timetable |
Route map
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Where to board in Wheeling Where you get off in St. Louis The route of the busiest trip
Where to catch the bus in Wheeling
- Wheeling Bus Stop Map of Wheeling Bus Stop (Google Maps)
Where the bus stops in St. Louis
- St Louis Bus Station Map of St Louis Bus Station (Google Maps)
Return trip: St. Louis to Wheeling
Questions
How long is the bus from Wheeling to St. Louis?
The fastest direct bus takes 11 hours 40 minutes.
What time is the first bus from Wheeling to St. Louis?
Every departure is at 9:15 PM (Daily).
Which bus companies go from Wheeling to St. Louis?
Greyhound runs direct buses on this route.
Where do I catch the bus in Wheeling?
Buses to St. Louis leave from Wheeling Bus Stop.