MO → WV · about 516 miles
St. Louis to Wheeling bus schedule
Greyhound runs 7 direct buses a week from St. Louis to Wheeling. The fastest takes 13 hours 20 minutes; every bus leaves at 2:00 AM.
Timetable data from · No schedule changes since at least
- Buses a week
- 7
- Fastest trip
- 13h 20m
- Leaves at
- 2:00 AM
Timetable
Every bus leaves from St Louis Bus Station and arrives at Wheeling Bus Stop. Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company |
|---|---|---|---|---|
| 2:00 AM | 4:20 PM | 13h 20m | Daily | Greyhound Full timetable |
Route map
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Where to board in St. Louis Where you get off in Wheeling The route of the busiest trip
Where to catch the bus in St. Louis
- St Louis Bus Station Map of St Louis Bus Station (Google Maps)
Where the bus stops in Wheeling
- Wheeling Bus Stop Map of Wheeling Bus Stop (Google Maps)
Return trip: Wheeling to St. Louis
Questions
How long is the bus from St. Louis to Wheeling?
The fastest direct bus takes 13 hours 20 minutes.
What time is the first bus from St. Louis to Wheeling?
Every departure is at 2:00 AM (Daily).
Which bus companies go from St. Louis to Wheeling?
Greyhound runs direct buses on this route.
Where do I catch the bus in St. Louis?
Buses to Wheeling leave from St Louis Bus Station.