MO → MO · about 98 miles
St. Louis to Cape Girardeau bus schedule
Greyhound runs 7 direct buses a week from St. Louis to Cape Girardeau. The fastest takes 2 hours 15 minutes; every bus leaves at 1:00 AM.
Timetable data from · No schedule changes since at least
- Buses a week
- 7
- Fastest trip
- 2h 15m
- Leaves at
- 1:00 AM
Timetable
Every bus leaves from St Louis Bus Station and arrives at Cape Girardeau Leming Lane. Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company |
|---|---|---|---|---|
| 1:00 AM | 3:15 AM | 2h 15m | Daily | Greyhound Full timetable |
Route map
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Where to board in St. Louis Where you get off in Cape Girardeau The route of the busiest trip
Where to catch the bus in St. Louis
- St Louis Bus Station Map of St Louis Bus Station (Google Maps)
Where the bus stops in Cape Girardeau
- Cape Girardeau Leming Lane Map of Cape Girardeau Leming Lane (Google Maps)
Return trip: Cape Girardeau to St. Louis
Questions
How long is the bus from St. Louis to Cape Girardeau?
The fastest direct bus takes 2 hours 15 minutes.
What time is the first bus from St. Louis to Cape Girardeau?
Every departure is at 1:00 AM (Daily).
Which bus companies go from St. Louis to Cape Girardeau?
Greyhound runs direct buses on this route.
Where do I catch the bus in St. Louis?
Buses to Cape Girardeau leave from St Louis Bus Station.