LA → MO · about 510 miles
New Orleans to Cape Girardeau bus schedule
Greyhound runs 7 direct buses a week from New Orleans to Cape Girardeau. The fastest takes 12 hours 40 minutes; every bus leaves at 8:20 AM.
Timetable data from · No schedule changes since at least
- Buses a week
- 7
- Fastest trip
- 12h 40m
- Leaves at
- 8:20 AM
Timetable
Every bus leaves from New Orleans Bus Station and arrives at Cape Girardeau Leming Lane. Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company |
|---|---|---|---|---|
| 8:20 AM | 9:00 PM | 12h 40m | Daily | Greyhound Full timetable |
Route map
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Where to board in New Orleans Where you get off in Cape Girardeau The route of the busiest trip
Where to catch the bus in New Orleans
- New Orleans Union Passenger Terminal Map of New Orleans Union Passenger Terminal (Google Maps)
Where the bus stops in Cape Girardeau
- Cape Girardeau Leming Lane Map of Cape Girardeau Leming Lane (Google Maps)
Return trip: Cape Girardeau to New Orleans
Questions
How long is the bus from New Orleans to Cape Girardeau?
The fastest direct bus takes 12 hours 40 minutes.
What time is the first bus from New Orleans to Cape Girardeau?
Every departure is at 8:20 AM (Daily).
Which bus companies go from New Orleans to Cape Girardeau?
Greyhound runs direct buses on this route.
Where do I catch the bus in New Orleans?
Buses to Cape Girardeau leave from New Orleans Union Passenger Terminal.