MS → MO · about 348 miles
Jackson to Cape Girardeau bus schedule
Greyhound runs 7 direct buses a week from Jackson to Cape Girardeau. The fastest takes 8 hours 5 minutes; every bus leaves at 12:55 PM.
Timetable data from · No schedule changes since at least
- Buses a week
- 7
- Fastest trip
- 8h 05m
- Leaves at
- 12:55 PM
Timetable
Every bus leaves from Jackson Union Station and arrives at Cape Girardeau Leming Lane. Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company |
|---|---|---|---|---|
| 12:55 PM | 9:00 PM | 8h 05m | Daily | Greyhound Full timetable |
Route map
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Where to board in Jackson Where you get off in Cape Girardeau The route of the busiest trip
Where to catch the bus in Jackson
- Jackson Union Station Map of Jackson Union Station (Google Maps)
Where the bus stops in Cape Girardeau
- Cape Girardeau Leming Lane Map of Cape Girardeau Leming Lane (Google Maps)
Return trip: Cape Girardeau to Jackson
Questions
How long is the bus from Jackson to Cape Girardeau?
The fastest direct bus takes 8 hours 5 minutes.
What time is the first bus from Jackson to Cape Girardeau?
Every departure is at 12:55 PM (Daily).
Which bus companies go from Jackson to Cape Girardeau?
Greyhound runs direct buses on this route.
Where do I catch the bus in Jackson?
Buses to Cape Girardeau leave from Jackson Union Station.