PA → MO · about 810 miles
Philadelphia to St. Louis bus schedule
Greyhound runs 14 direct buses a week from Philadelphia to St. Louis. The fastest takes 20 hours 50 minutes; the first bus leaves at 12:05 PM and the last at 5:35 PM.
Timetable data from · No schedule changes since at least
- Buses a week
- 14
- Fastest trip
- 20h 50m
- First bus
- 12:05 PM
- Last bus
- 5:35 PM
Timetable
Every bus leaves from Philadelphia and arrives at St Louis Bus Station. Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company |
|---|---|---|---|---|
| 12:05 PM | 7:55 AM +1 day | 20h 50m | Daily | Greyhound Full timetable |
| 5:35 PM | 3:10 PM +1 day | 22h 35m | Daily | Greyhound Full timetable |
Route map
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Where to board in Philadelphia Where you get off in St. Louis The route of the busiest trip
Where to catch the bus in Philadelphia
Where the bus stops in St. Louis
- St Louis Bus Station Map of St Louis Bus Station (Google Maps)
Return trip: St. Louis to Philadelphia
Questions
How long is the bus from Philadelphia to St. Louis?
The fastest direct bus takes 20 hours 50 minutes.
What time is the first bus from Philadelphia to St. Louis?
The earliest departure is at 12:05 PM (Daily) and the last at 5:35 PM (Daily).
Which bus companies go from Philadelphia to St. Louis?
Greyhound runs direct buses on this route.
Where do I catch the bus in Philadelphia?
Buses to St. Louis leave from Philadelphia (Bus Terminal).