MO → PA · about 810 miles
St. Louis to Philadelphia bus schedule
Greyhound runs 21 direct buses a week from St. Louis to Philadelphia. The fastest takes 22 hours 5 minutes; the first bus leaves at 2:00 AM and the last at 2:05 PM.
Timetable data from · No schedule changes since at least
- Buses a week
- 21
- Fastest trip
- 22h 05m
- First bus
- 2:00 AM
- Last bus
- 2:05 PM
Timetable
Every bus leaves from St Louis Bus Station and arrives at Philadelphia. Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company |
|---|---|---|---|---|
| 2:00 AM | 2:00 AM +1 day | 23h 00m | Daily | Greyhound Full timetable |
| 8:45 AM | 8:10 AM +1 day | 22h 25m | Daily | Greyhound Full timetable |
| 2:05 PM | 1:10 PM +1 day | 22h 05m | Daily | Greyhound Full timetable |
Route map
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Where to board in St. Louis Where you get off in Philadelphia The route of the busiest trip
Where to catch the bus in St. Louis
- St Louis Bus Station Map of St Louis Bus Station (Google Maps)
Where the bus stops in Philadelphia
Return trip: Philadelphia to St. Louis
Questions
How long is the bus from St. Louis to Philadelphia?
The fastest direct bus takes 22 hours 5 minutes; the typical trip is 22 hours 25 minutes.
What time is the first bus from St. Louis to Philadelphia?
The earliest departure is at 2:00 AM (Daily) and the last at 2:05 PM (Daily).
Which bus companies go from St. Louis to Philadelphia?
Greyhound runs direct buses on this route.
Where do I catch the bus in St. Louis?
Buses to Philadelphia leave from St Louis Bus Station.