KY → MO · about 140 miles
Paducah to St. Louis bus schedule
FlixBus runs 5 direct buses a week from Paducah to St. Louis. The fastest takes 3 hours 25 minutes; every bus leaves at 5:55 AM.
Timetable data from · No schedule changes since at least
- Buses a week
- 5
- Fastest trip
- 3h 25m
- Leaves at
- 5:55 AM
Timetable
Every bus leaves from Paducah KY (PAD) and arrives at St Louis Bus Station. Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company |
|---|---|---|---|---|
| 5:55 AM | 9:20 AM | 3h 25m | Mon, Thu, Fri, Sat, Sun | FlixBus Full timetable |
Route map
The map needs JavaScript.
Where to board in Paducah Where you get off in St. Louis The route of the busiest trip
Where to catch the bus in Paducah
- Paducah KY (PAD) Map of Paducah KY (PAD) (Google Maps)
Where the bus stops in St. Louis
- St Louis Bus Station Map of St Louis Bus Station (Google Maps)
Return trip: St. Louis to Paducah
Questions
How long is the bus from Paducah to St. Louis?
The fastest direct bus takes 3 hours 25 minutes.
What time is the first bus from Paducah to St. Louis?
Every departure is at 5:55 AM (Mon, Thu, Fri, Sat, Sun).
Which bus companies go from Paducah to St. Louis?
FlixBus runs direct buses on this route.
Where do I catch the bus in Paducah?
Buses to St. Louis leave from Paducah KY (PAD).