SC → FL · about 222 miles
Orangeburg to Jacksonville bus schedule
FlixBus and Greyhound run 14 direct buses a week from Orangeburg to Jacksonville. The fastest takes 4 hours 40 minutes; the first bus leaves at 1:45 PM and the last at 5:05 PM.
Timetable data from · No schedule changes since at least
- Buses a week
- 14
- Fastest trip
- 4h 40m
- First bus
- 1:45 PM
- Last bus
- 5:05 PM
Timetable
Every bus leaves from Orangeburg (Xpress Travel Center) and arrives at Jacksonville Greyhound Bus Station. Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company |
|---|---|---|---|---|
| 1:45 PM | 6:25 PM | 4h 40m | Daily | FlixBus Full timetable |
| 5:05 PM | 9:55 PM | 4h 50m | Daily | Greyhound Full timetable |
Route map
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Where to board in Orangeburg Where you get off in Jacksonville The route of the busiest trip
Where to catch the bus in Orangeburg
- Orangeburg (Xpress Travel Center) Map of Orangeburg (Xpress Travel Center) (Google Maps)
Where the bus stops in Jacksonville
Return trip: Jacksonville to Orangeburg
Questions
How long is the bus from Orangeburg to Jacksonville?
The fastest direct bus takes 4 hours 40 minutes.
What time is the first bus from Orangeburg to Jacksonville?
The earliest departure is at 1:45 PM (Daily) and the last at 5:05 PM (Daily).
Which bus companies go from Orangeburg to Jacksonville?
FlixBus and Greyhound run direct buses on this route.
Where do I catch the bus in Orangeburg?
Buses to Jacksonville leave from Orangeburg (Xpress Travel Center).