FL → SC · about 222 miles
Jacksonville to Orangeburg bus schedule
FlixBus and Greyhound run 14 direct buses a week from Jacksonville to Orangeburg. The fastest takes 4 hours 25 minutes; the first bus leaves at 8:10 AM and the last at 5:25 PM.
Timetable data from · No schedule changes since at least
- Buses a week
- 14
- Fastest trip
- 4h 25m
- First bus
- 8:10 AM
- Last bus
- 5:25 PM
Timetable
Every bus leaves from Jacksonville Greyhound Bus Station and arrives at Orangeburg (Xpress Travel Center). Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company |
|---|---|---|---|---|
| 8:10 AM | 12:50 PM | 4h 40m | Daily | Greyhound Full timetable |
| 5:25 PM | 9:50 PM | 4h 25m | Daily | FlixBus Full timetable |
Route map
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Where to board in Jacksonville Where you get off in Orangeburg The route of the busiest trip
Where to catch the bus in Jacksonville
Where the bus stops in Orangeburg
- Orangeburg (Xpress Travel Center) Map of Orangeburg (Xpress Travel Center) (Google Maps)
Return trip: Orangeburg to Jacksonville
Questions
How long is the bus from Jacksonville to Orangeburg?
The fastest direct bus takes 4 hours 25 minutes.
What time is the first bus from Jacksonville to Orangeburg?
The earliest departure is at 8:10 AM (Daily) and the last at 5:25 PM (Daily).
Which bus companies go from Jacksonville to Orangeburg?
FlixBus and Greyhound run direct buses on this route.
Where do I catch the bus in Jacksonville?
Buses to Orangeburg leave from Jacksonville Greyhound Bus Station.