TN → MO · about 245 miles
Memphis to St. Louis bus schedule
FlixBus and Greyhound run 12 direct buses a week from Memphis to St. Louis. The fastest takes 4 hours 45 minutes; the first bus leaves at 9:30 AM and the last at 5:45 PM.
Timetable data from · Schedule last changed
- Buses a week
- 12
- Fastest trip
- 4h 45m
- First bus
- 9:30 AM
- Last bus
- 5:45 PM
Timetable
Every bus leaves from Memphis Greyhound Bus Station and arrives at St Louis Bus Station. Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company |
|---|---|---|---|---|
| 9:30 AM | 2:15 PM | 4h 45m | Mon, Tue, Fri, Sat, Sun | FlixBus Full timetable |
| 5:45 PM | 11:00 PM | 5h 15m | Daily | Greyhound Full timetable |
Route map
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Where to board in Memphis Where you get off in St. Louis The route of the busiest trip
Where to catch the bus in Memphis
Where the bus stops in St. Louis
- St Louis Bus Station Map of St Louis Bus Station (Google Maps)
Return trip: St. Louis to Memphis
Questions
How long is the bus from Memphis to St. Louis?
The fastest direct bus takes 4 hours 45 minutes.
What time is the first bus from Memphis to St. Louis?
The earliest departure is at 9:30 AM (Mon, Tue, Fri, Sat, Sun) and the last at 5:45 PM (Daily).
Which bus companies go from Memphis to St. Louis?
FlixBus and Greyhound run direct buses on this route.
Where do I catch the bus in Memphis?
Buses to St. Louis leave from Memphis (Airport).