MO → TN · about 245 miles
St. Louis to Memphis bus schedule
FlixBus and Greyhound run 12 direct buses a week from St. Louis to Memphis. The fastest takes 4 hours 45 minutes; the first bus leaves at 1:00 AM and the last at 4:00 PM.
Timetable data from · Schedule last changed
- Buses a week
- 12
- Fastest trip
- 4h 45m
- First bus
- 1:00 AM
- Last bus
- 4:00 PM
Timetable
Every bus leaves from St Louis Bus Station and arrives at Memphis Greyhound Bus Station. Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company |
|---|---|---|---|---|
| 1:00 AM | 6:30 AM | 5h 30m | Daily | Greyhound Full timetable |
| 4:00 PM | 8:45 PM | 4h 45m | Mon, Thu, Fri, Sat, Sun | FlixBus Full timetable |
Route map
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Where to board in St. Louis Where you get off in Memphis The route of the busiest trip
Where to catch the bus in St. Louis
- St Louis Bus Station Map of St Louis Bus Station (Google Maps)
Where the bus stops in Memphis
Return trip: Memphis to St. Louis
Questions
How long is the bus from St. Louis to Memphis?
The fastest direct bus takes 4 hours 45 minutes.
What time is the first bus from St. Louis to Memphis?
The earliest departure is at 1:00 AM (Daily) and the last at 4:00 PM (Mon, Thu, Fri, Sat, Sun).
Which bus companies go from St. Louis to Memphis?
FlixBus and Greyhound run direct buses on this route.
Where do I catch the bus in St. Louis?
Buses to Memphis leave from St Louis Bus Station.