CA → MO · about 1,589 miles
Los Angeles to St. Louis bus & train schedule
Amtrak and Greyhound run 3 direct buses and trains a week from Los Angeles to St. Louis. The fastest takes 40 hours 10 minutes; the first departure leaves at 12:55 PM and the last at 10:00 PM.
Timetable data from · Schedule last changed
- Buses and trains a week
- 3
- Fastest trip
- 40h 10m
- First departure
- 12:55 PM
- Last departure
- 10:00 PM
Timetable
Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Stops | Company |
|---|---|---|---|---|---|
| 12:55 PM New | 7:05 AM +2 day | 40h 10m | Daily from Nov 2 | Los Angeles Union Station to St Louis Bus Station | Greyhound Full timetable |
| 10:00 PM | 7:30 AM +3 day | 55h 30m | Tue, Thu, Sat | Los Angeles to St. Louis | Amtrak Full timetable |
Route map
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Where to board in Los Angeles Where you get off in St. Louis The route of the busiest trip
Where to board in Los Angeles
Where buses and trains stop in St. Louis
- St Louis Bus Station Map of St Louis Bus Station (Google Maps)
Return trip: St. Louis to Los Angeles
Questions
How long is the bus or train from Los Angeles to St. Louis?
The fastest direct bus or train takes 40 hours 10 minutes; the typical trip is 55 hours 30 minutes.
What time is the first departure from Los Angeles to St. Louis?
The earliest departure is at 12:55 PM (Daily) and the last at 10:00 PM (Tue, Thu, Sat).
Which bus and rail companies go from Los Angeles to St. Louis?
Amtrak and Greyhound run direct buses and trains on this route.
Where do I board in Los Angeles?
Buses and trains to St. Louis leave from Los Angeles (Americanstar) and Los Angeles (Union Station).