MO → CA · about 1,589 miles
St. Louis to Los Angeles bus & train schedule
Amtrak and Greyhound run 10 direct buses and trains a week from St. Louis to Los Angeles. The fastest takes 40 hours 30 minutes; the first departure leaves at 1:20 AM and the last at 8:10 PM.
Timetable data from · No schedule changes since at least
- Buses and trains a week
- 10
- Fastest trip
- 40h 30m
- First departure
- 1:20 AM
- Last departure
- 8:10 PM
Timetable
Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Stops | Company |
|---|---|---|---|---|---|
| 1:20 AM | 3:50 PM +1 day | 40h 30m | Daily | St Louis Bus Station to Los Angeles Union Station | Greyhound Full timetable |
| 8:10 PM | 5:35 AM +3 day | 59h 25m | Tue, Fri, Sun | St. Louis to Los Angeles | Amtrak Full timetable |
Route map
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Where to board in St. Louis Where you get off in Los Angeles The route of the busiest trip
Where to board in St. Louis
- St Louis Bus Station Map of St Louis Bus Station (Google Maps)
Where buses and trains stop in Los Angeles
Return trip: Los Angeles to St. Louis
Questions
How long is the bus or train from St. Louis to Los Angeles?
The fastest direct bus or train takes 40 hours 30 minutes; the typical trip is 59 hours 25 minutes.
What time is the first departure from St. Louis to Los Angeles?
The earliest departure is at 1:20 AM (Daily) and the last at 8:10 PM (Tue, Fri, Sun).
Which bus and rail companies go from St. Louis to Los Angeles?
Amtrak and Greyhound run direct buses and trains on this route.
Where do I board in St. Louis?
Buses and trains to Los Angeles leave from St Louis Bus Station.