NE → IA · about 325 miles
Lexington to Des Moines bus schedule
Greyhound runs 7 direct buses a week from Lexington to Des Moines. The fastest takes 7 hours 35 minutes; every bus leaves at 1:20 AM.
Timetable data from · No schedule changes since at least
- Buses a week
- 7
- Fastest trip
- 7h 35m
- Leaves at
- 1:20 AM
Timetable
Every bus leaves from Lexington Phillips 66 and arrives at Des Moines. Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company |
|---|---|---|---|---|
| 1:20 AM | 8:55 AM | 7h 35m | Daily | Greyhound Full timetable |
Route map
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Where to board in Lexington Where you get off in Des Moines The route of the busiest trip
Where to catch the bus in Lexington
- Lexington Phillips 66 Map of Lexington Phillips 66 (Google Maps)
Where the bus stops in Des Moines
- Des Moines bus stop Map of Des Moines bus stop (Google Maps)
Return trip: Des Moines to Lexington
Questions
How long is the bus from Lexington to Des Moines?
The fastest direct bus takes 7 hours 35 minutes.
What time is the first bus from Lexington to Des Moines?
Every departure is at 1:20 AM (Daily).
Which bus companies go from Lexington to Des Moines?
Greyhound runs direct buses on this route.
Where do I catch the bus in Lexington?
Buses to Des Moines leave from Lexington Phillips 66.