IA → NE · about 325 miles
Des Moines to Lexington bus schedule
Greyhound runs 7 direct buses a week from Des Moines to Lexington. The fastest takes 8 hours 45 minutes; every bus leaves at 7:35 PM.
Timetable data from · No schedule changes since at least
- Buses a week
- 7
- Fastest trip
- 8h 45m
- Leaves at
- 7:35 PM
Timetable
Every bus leaves from Des Moines and arrives at Lexington Phillips 66. Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company |
|---|---|---|---|---|
| 7:35 PM | 4:20 AM +1 day | 8h 45m | Daily | Greyhound Full timetable |
Route map
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Where to board in Des Moines Where you get off in Lexington The route of the busiest trip
Where to catch the bus in Des Moines
- Des Moines bus stop Map of Des Moines bus stop (Google Maps)
Where the bus stops in Lexington
- Lexington Phillips 66 Map of Lexington Phillips 66 (Google Maps)
Return trip: Lexington to Des Moines
Questions
How long is the bus from Des Moines to Lexington?
The fastest direct bus takes 8 hours 45 minutes.
What time is the first bus from Des Moines to Lexington?
Every departure is at 7:35 PM (Daily).
Which bus companies go from Des Moines to Lexington?
Greyhound runs direct buses on this route.
Where do I catch the bus in Des Moines?
Buses to Lexington leave from Des Moines bus stop.