Bus stops in Iowa

Bus schedules for Des Moines, IA

Jefferson Lines and Greyhound run 117 departures a week from Des Moines to 56 destinations. The first bus leaves at 12:01 AM and the last at 11:55 PM.

Timetable data from · Schedule last changed

Departures a week
117
Destinations
56
Bus companies
2
Bus stops
1

Where the bus stops in Des Moines

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Where you can go from Des Moines

Direct buses, no changes. Pick a destination for its full timetable.

Direct destinations from Des Moines, IA
DestinationBuses a weekFastestBus companyStandard fare & ticket
Iowa City, IA40 buses a weekFastest 1h 45mJefferson Lines and Greyhoundfrom $17Book (carrier website)
Davenport, IA33 buses a weekFastest 2h 45mJefferson Lines and Greyhound$45Book (carrier website)
Ames, IA33 buses a weekFastest 30mJefferson Lines and Greyhound$18Book (carrier website)
Albert Lea, MN MCW airport28 buses a weekFastest 2h 30mJefferson Lines and Greyhound$35Book (carrier website)
Minneapolis, MN MCW airport28 buses a weekFastest 4h 25mJefferson Lines and Greyhound$55Book (carrier website)
Kansas City, MO28 buses a weekFastest 3h 00mJefferson Lines and Greyhound$40Book (carrier website)
Chicago, IL26 buses a weekFastest 6h 00mJefferson Lines and Greyhound$87Book (carrier website)
Owatonna, MN MCW airport21 buses a weekFastest 3h 14mJefferson Lines$40Book (carrier website)
Lamoni, IA21 buses a weekFastest 1h 15mJefferson Lines$16Book (carrier website)
Bethany, MO21 buses a weekFastest 1h 40mJefferson Lines and Greyhound$25Book (carrier website)
Moline, IL19 buses a weekFastest 3h 45mJefferson Lines and Greyhound$69Book (carrier website)
Omaha, NE14 buses a weekFastest 2h 15mJefferson Lines and Greyhound$35Book (carrier website)
Cedar Rapids, IA14 buses a weekFastest 2h 00mJefferson Linesfrom $21Book (carrier website)
Galesburg, IL14 buses a weekFastest 4h 30mJefferson Lines and Greyhound$63Book (carrier website)
Bloomington, IL14 buses a weekFastest 6h 10mJefferson Lines and Greyhound$80Book (carrier website)
Champaign, IL14 buses a weekFastest 7h 15mJefferson Lines and Greyhound$95Book (carrier website)
Indianapolis, IN14 buses a weekFastest 9h 25mJefferson Lines and Greyhound$123Book (carrier website)
Faribault, MN MCW airport14 buses a weekFastest 4h 00mJefferson Linesfrom $83Book (carrier website)
Burnsville, MN MCW airport14 buses a weekFastest 4h 40mJefferson Lines$50Book (carrier website)
Osceola, IA14 buses a weekFastest 44mJefferson Lines$10Book (carrier website)
Clear Lake, IA14 buses a weekFastest 1h 45mJefferson Lines$25Book (carrier website)
Grinnell, IA14 buses a weekFastest 55mGreyhoundFare not listed, no online booking link
Marshalltown, IA12 buses a weekFastest 55mJefferson Lines and Greyhound$27Book (carrier website)
Peoria, IL7 buses a weekFastest 6h 10mJefferson Lines$75Book (carrier website)
Danville, IL7 buses a weekFastest 9h 00mJefferson Lines$117Book (carrier website)
Williams, IA7 buses a weekFastest 1h 15mJefferson Lines$40Book (carrier website)
Latimer, IA7 buses a weekFastest 1h 45mJefferson Lines$53Book (carrier website)
Mason City, IA MCW airport7 buses a weekFastest 2h 25mJefferson Lines$64Book (carrier website)
Williamsburg, IA7 buses a weekFastest 1h 20mJefferson Lines$14Book (carrier website)
Cedar Falls, IA New7 buses a weekFastest 4h 00mJefferson Lines$30Book (carrier website)
Iola, KS7 buses a weekFastest 7h 04mJefferson Lines$115Book (carrier website)
Chanute, KS7 buses a weekFastest 7h 29mJefferson Lines$121Book (carrier website)
Coffeyville, KS7 buses a weekFastest 8h 34mJefferson Lines$148Book (carrier website)
Dewey, OK7 buses a weekFastest 9h 09mJefferson Lines$156Book (carrier website)
Tulsa, OK7 buses a weekFastest 10h 14mJefferson Lines$161Book (carrier website)
Cameron, MO7 buses a weekFastest 2h 40mJefferson Lines$30Book (carrier website)
St. Paul, MN7 buses a weekFastest 5h 10mJefferson Lines$55Book (carrier website)
Dixon, IL7 buses a weekFastest 5h 05mGreyhoundFare not listed, no online booking link
Rochelle, IL7 buses a weekFastest 5h 45mGreyhoundFare not listed, no online booking link
DeKalb, IL7 buses a weekFastest 6h 25mGreyhoundFare not listed, no online booking link
Naperville, IL7 buses a weekFastest 7h 15mGreyhoundFare not listed, no online booking link
Lincoln, NE7 buses a weekFastest 4h 35mGreyhoundFare not listed, no online booking link
York, NE7 buses a weekFastest 5h 40mGreyhoundFare not listed, no online booking link
Grand Island, NE7 buses a weekFastest 6h 55mGreyhoundFare not listed, no online booking link
Kearney, NE7 buses a weekFastest 7h 55mGreyhoundFare not listed, no online booking link
Lexington, NE7 buses a weekFastest 8h 45mGreyhoundFare not listed, no online booking link
North Platte, NE7 buses a weekFastest 9h 50mGreyhoundFare not listed, no online booking link
Ogallala, NE7 buses a weekFastest 10h 50mGreyhoundFare not listed, no online booking link
Denver, CO7 buses a weekFastest 14h 25mGreyhoundFare not listed, no online booking link
Monroe, IA New7 buses a weekFastest 40mGreyhoundFare not listed, no online booking link
Oskaloosa, IA New7 buses a weekFastest 1h 15mGreyhoundFare not listed, no online booking link
Ottumwa, IA New7 buses a weekFastest 1h 50mGreyhoundFare not listed, no online booking link
Burlington, IA New7 buses a weekFastest 3h 10mGreyhoundFare not listed, no online booking link
Waterloo, IA5 buses a weekFastest 2h 55mGreyhoundFare not listed, no online booking link
Marion, IA5 buses a weekFastest 4h 05mGreyhoundFare not listed, no online booking link
Rockford, IL5 buses a weekFastest 8h 20mGreyhoundFare not listed, no online booking link

A standard fare is the carrier's published one-way price. Many carriers price by demand, so the fare when you book can be higher or lower. Fares don't include any fees the carrier's ticket site may add; BusSchedules.com adds no fees. A dash means the fare isn’t listed here.

Departures from Des Moines

Every bus leaving Des Moines, by time of day. Times are local. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.

Departures from Des Moines, IA
DepartsGoing toDaysStopBus companyTicket
12:01 AMTulsaDailyDes Moines bus stopJefferson LinesBook (carrier website)
12:01 AMMinneapolisDailyDes Moines bus stopJefferson LinesBook (carrier website)
3:40 AMKansas CityDailyDes Moines bus stopJefferson LinesBook (carrier website)
3:45 AMOmahaDailyDes Moines bus stopJefferson LinesBook (carrier website)
4:05 AMMinneapolisDailyDes Moines bus stopJefferson LinesBook (carrier website)
5:25 AM NewKansas CityDailyDes Moines bus stopGreyhoundNo online booking link
5:30 AMChicagoDailyDes Moines bus stopGreyhoundNo online booking link
7:50 AM NewIndianapolisDailyDes Moines bus stopGreyhoundNo online booking link
8:30 AMIndianapolisDailyDes Moines bus stopJefferson LinesBook (carrier website)
9:20 AMChicagoDailyDes Moines bus stopGreyhoundNo online booking link
9:45 AMChicagoMon, Thu, Fri, Sat, SunDes Moines bus stopGreyhoundNo online booking link
12:15 PMMinneapolis MCW airportDailyDes Moines bus stopJefferson LinesBook (carrier website)
1:00 PMCedar FallsDailyDes Moines bus stopJefferson LinesBook (carrier website)
7:10 PMKansas CityDailyDes Moines bus stopJefferson LinesBook (carrier website)
7:35 PMDenverDailyDes Moines bus stopGreyhoundNo online booking link
11:45 PMChicagoDailyDes Moines bus stopJefferson LinesBook (carrier website)
11:55 PM NewMinneapolisDailyDes Moines bus stopGreyhoundNo online booking link

Nearby towns with service