IA → IN · about 409 miles
Des Moines to Indianapolis bus schedule
Jefferson Lines and Greyhound run 14 direct buses a week from Des Moines to Indianapolis. The fastest takes 9 hours 25 minutes; the first bus leaves at 7:50 AM and the last at 8:30 AM. The standard fare with Jefferson Lines is $123 one way.
Timetable data from · Schedule last changed
- Buses a week
- 14
- Fastest trip
- 9h 25m
- First bus
- 7:50 AM
- Last bus
- 8:30 AM
- Standard fare
- $123
A standard fare is the carrier's published one-way price. Many carriers price by demand, so the fare when you book can be higher or lower. Fares don't include any fees the carrier's ticket site may add; BusSchedules.com adds no fees. Fares for Greyhound aren't listed here.
Timetable
Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Stops | Bus company | Standard fare & ticket |
|---|---|---|---|---|---|---|
| 7:50 AM New | 6:15 PM | 9h 25m | Daily | Des Moines to Indianapolis Bus Station | Greyhound Full timetable | Fare not listed, no online booking link |
| 8:30 AM | 7:50 PM | 10h 20m | Daily | Des Moines to Indianapolis | Jefferson Lines Full timetable | $123Book (carrier website) |
Route map
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Where to board in Des Moines Where you get off in Indianapolis The route of the busiest trip
Where to catch the bus in Des Moines
- Des Moines bus stop Map of Des Moines bus stop (Google Maps)
Where the bus stops in Indianapolis
Return trip: Indianapolis to Des Moines
Questions
How long is the bus from Des Moines to Indianapolis?
The fastest direct bus takes 9 hours 25 minutes.
How much is the bus from Des Moines to Indianapolis?
The standard one-way fare with Jefferson Lines is $123. Many carriers price by demand, so the fare when you book can be higher or lower. Fares don't include any fees the carrier's ticket site may add; BusSchedules.com adds no fees. Fares for Greyhound aren't listed here; check its website.
What time is the first bus from Des Moines to Indianapolis?
The earliest departure is at 7:50 AM (Daily) and the last at 8:30 AM (Daily).
Which bus companies go from Des Moines to Indianapolis?
Jefferson Lines and Greyhound run direct buses on this route.
Where do I catch the bus in Des Moines?
Buses to Indianapolis leave from Des Moines bus stop.