MO → MO · about 106 miles
Jefferson City to St. Louis bus & train schedule
Amtrak and Greyhound run 21 direct buses and trains a week from Jefferson City to St. Louis. The fastest takes 2 hours 31 minutes; the first departure leaves at 11:49 AM and the last at 7:15 PM.
Timetable data from · No schedule changes since at least
- Buses and trains a week
- 21
- Fastest trip
- 2h 31m
- First departure
- 11:49 AM
- Last departure
- 7:15 PM
Timetable
Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Stops | Company |
|---|---|---|---|---|---|
| 11:49 AM | 2:20 PM | 2h 31m | Daily | Jefferson City Amtrak Station to St. Louis | Amtrak Full timetable |
| 7:12 PM | 9:45 PM | 2h 33m | Daily | Jefferson City Amtrak Station to St. Louis | Amtrak Full timetable |
| 7:15 PM | 10:55 PM | 3h 40m | Daily | Jefferson City Conoco to St Louis Bus Station | Greyhound Full timetable |
Route map
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Where to board in Jefferson City Where you get off in St. Louis The route of the busiest trip
Where to board in Jefferson City
Where buses and trains stop in St. Louis
- St Louis Bus Station Map of St Louis Bus Station (Google Maps)
Return trip: St. Louis to Jefferson City
Questions
How long is the bus or train from Jefferson City to St. Louis?
The fastest direct bus or train takes 2 hours 31 minutes; the typical trip is 2 hours 33 minutes.
What time is the first departure from Jefferson City to St. Louis?
The earliest departure is at 11:49 AM (Daily) and the last at 7:15 PM (Daily).
Which bus and rail companies go from Jefferson City to St. Louis?
Amtrak and Greyhound run direct buses and trains on this route.
Where do I board in Jefferson City?
Buses and trains to St. Louis leave from Jefferson City Amtrak Station and Jefferson City Conoco.