PA → MO · about 720 miles
Harrisburg to St. Louis bus schedule
Greyhound runs 14 direct buses a week from Harrisburg to St. Louis. The fastest takes 18 hours 5 minutes; the first bus leaves at 2:50 PM and the last at 7:50 PM.
Timetable data from · No schedule changes since at least
- Buses a week
- 14
- Fastest trip
- 18h 05m
- First bus
- 2:50 PM
- Last bus
- 7:50 PM
Timetable
Every bus leaves from Harrisburg Market St Train Station and arrives at St Louis Bus Station. Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company |
|---|---|---|---|---|
| 2:50 PM | 7:55 AM +1 day | 18h 05m | Daily | Greyhound Full timetable |
| 7:50 PM | 3:10 PM +1 day | 20h 20m | Daily | Greyhound Full timetable |
Route map
The map needs JavaScript.
Where to board in Harrisburg Where you get off in St. Louis The route of the busiest trip
Where to catch the bus in Harrisburg
Where the bus stops in St. Louis
- St Louis Bus Station Map of St Louis Bus Station (Google Maps)
Return trip: St. Louis to Harrisburg
Questions
How long is the bus from Harrisburg to St. Louis?
The fastest direct bus takes 18 hours 5 minutes.
What time is the first bus from Harrisburg to St. Louis?
The earliest departure is at 2:50 PM (Daily) and the last at 7:50 PM (Daily).
Which bus companies go from Harrisburg to St. Louis?
Greyhound runs direct buses on this route.
Where do I catch the bus in Harrisburg?
Buses to St. Louis leave from Harrisburg Market St Train Station.