MO → PA · about 720 miles
St. Louis to Harrisburg bus schedule
Greyhound runs 21 direct buses a week from St. Louis to Harrisburg. The fastest takes 19 hours 20 minutes; the first bus leaves at 2:00 AM and the last at 2:05 PM.
Timetable data from · No schedule changes since at least
- Buses a week
- 21
- Fastest trip
- 19h 20m
- First bus
- 2:00 AM
- Last bus
- 2:05 PM
Timetable
Every bus leaves from St Louis Bus Station and arrives at Harrisburg Market St Train Station. Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company |
|---|---|---|---|---|
| 2:00 AM | 11:15 PM | 20h 15m | Daily | Greyhound Full timetable |
| 8:45 AM | 5:35 AM +1 day | 19h 50m | Daily | Greyhound Full timetable |
| 2:05 PM | 10:25 AM +1 day | 19h 20m | Daily | Greyhound Full timetable |
Route map
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Where to board in St. Louis Where you get off in Harrisburg The route of the busiest trip
Where to catch the bus in St. Louis
- St Louis Bus Station Map of St Louis Bus Station (Google Maps)
Where the bus stops in Harrisburg
Return trip: Harrisburg to St. Louis
Questions
How long is the bus from St. Louis to Harrisburg?
The fastest direct bus takes 19 hours 20 minutes; the typical trip is 19 hours 50 minutes.
What time is the first bus from St. Louis to Harrisburg?
The earliest departure is at 2:00 AM (Daily) and the last at 2:05 PM (Daily).
Which bus companies go from St. Louis to Harrisburg?
Greyhound runs direct buses on this route.
Where do I catch the bus in St. Louis?
Buses to Harrisburg leave from St Louis Bus Station.