CO → MO · about 792 miles
Denver to St. Louis bus schedule
Greyhound runs 7 direct buses a week from Denver to St. Louis. The fastest takes 17 hours 35 minutes; every bus leaves at 1:35 PM.
Timetable data from · Schedule last changed
- Buses a week
- 7
- Fastest trip
- 17h 35m
- Leaves at
- 1:35 PM
Timetable
Every bus leaves from Denver Union Station Bus Concourse and arrives at St Louis Bus Station. Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company |
|---|---|---|---|---|
| 1:35 PM | 8:10 AM +1 day | 17h 35m | Daily | Greyhound Full timetable |
Route map
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Where to board in Denver Where you get off in St. Louis The route of the busiest trip
Where to catch the bus in Denver
Where the bus stops in St. Louis
- St Louis Bus Station Map of St Louis Bus Station (Google Maps)
Return trip: St. Louis to Denver
Questions
How long is the bus from Denver to St. Louis?
The fastest direct bus takes 17 hours 35 minutes.
What time is the first bus from Denver to St. Louis?
Every departure is at 1:35 PM (Daily).
Which bus companies go from Denver to St. Louis?
Greyhound runs direct buses on this route.
Where do I catch the bus in Denver?
Buses to St. Louis leave from Denver Union Station Bus Concourse.