TN → MO · about 219 miles
Clarksville to St. Louis bus schedule
FlixBus and Greyhound run 19 direct buses a week from Clarksville to St. Louis. The fastest takes 5 hours 5 minutes; the first bus leaves at 4:15 AM and the last at 3:55 PM.
Timetable data from · No schedule changes since at least
- Buses a week
- 19
- Fastest trip
- 5h 05m
- First bus
- 4:15 AM
- Last bus
- 3:55 PM
Timetable
Every bus leaves from Clarksville TN (CRK) and arrives at St Louis Bus Station. Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company |
|---|---|---|---|---|
| 4:15 AM | 9:20 AM | 5h 05m | Mon, Thu, Fri, Sat, Sun | FlixBus Full timetable |
| 10:05 AM | 3:55 PM | 5h 50m | Daily | Greyhound Full timetable |
| 3:55 PM | 9:30 PM | 5h 35m | Daily | Greyhound Full timetable |
Route map
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Where to board in Clarksville Where you get off in St. Louis The route of the busiest trip
Where to catch the bus in Clarksville
- Clarksville TN (CRK) Map of Clarksville TN (CRK) (Google Maps)
Where the bus stops in St. Louis
- St Louis Bus Station Map of St Louis Bus Station (Google Maps)
Return trip: St. Louis to Clarksville
Questions
How long is the bus from Clarksville to St. Louis?
The fastest direct bus takes 5 hours 5 minutes; the typical trip is 5 hours 35 minutes.
What time is the first bus from Clarksville to St. Louis?
The earliest departure is at 4:15 AM (Mon, Thu, Fri, Sat, Sun) and the last at 3:55 PM (Daily).
Which bus companies go from Clarksville to St. Louis?
FlixBus and Greyhound run direct buses on this route.
Where do I catch the bus in Clarksville?
Buses to St. Louis leave from Clarksville TN (CRK).