MO → TN · about 219 miles
St. Louis to Clarksville bus schedule
FlixBus and Greyhound run 19 direct buses a week from St. Louis to Clarksville. The fastest takes 5 hours; the first bus leaves at 9:00 AM and the last at 11:45 PM.
Timetable data from · No schedule changes since at least
- Buses a week
- 19
- Fastest trip
- 5h 00m
- First bus
- 9:00 AM
- Last bus
- 11:45 PM
Timetable
Every bus leaves from St Louis Bus Station and arrives at Clarksville TN (CRK). Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company |
|---|---|---|---|---|
| 9:00 AM | 2:40 PM | 5h 40m | Daily | Greyhound Full timetable |
| 1:45 PM | 7:50 PM | 6h 05m | Daily | Greyhound Full timetable |
| 11:45 PM | 4:45 AM +1 day | 5h 00m | Mon, Thu, Fri, Sat, Sun | FlixBus Full timetable |
Route map
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Where to board in St. Louis Where you get off in Clarksville The route of the busiest trip
Where to catch the bus in St. Louis
- St Louis Bus Station Map of St Louis Bus Station (Google Maps)
Where the bus stops in Clarksville
- Clarksville TN (CRK) Map of Clarksville TN (CRK) (Google Maps)
Return trip: Clarksville to St. Louis
Questions
How long is the bus from St. Louis to Clarksville?
The fastest direct bus takes 5 hours; the typical trip is 5 hours 40 minutes.
What time is the first bus from St. Louis to Clarksville?
The earliest departure is at 9:00 AM (Daily) and the last at 11:45 PM (Mon, Thu, Fri, Sat, Sun).
Which bus companies go from St. Louis to Clarksville?
FlixBus and Greyhound run direct buses on this route.
Where do I catch the bus in St. Louis?
Buses to Clarksville leave from St Louis Bus Station.