MO → MO · about 195 miles
Springfield to St. Louis bus schedule
Greyhound runs 7 direct buses a week from Springfield to St. Louis. The fastest takes 3 hours 40 minutes; the first bus leaves at 3:25 AM and the last at 6:35 PM.
Timetable data from · Schedule last changed
- Buses a week
- 7
- Fastest trip
- 3h 40m
- First bus
- 3:25 AM
- Last bus
- 6:35 PM
Timetable
Every bus leaves from Springfield Cu Transit Center and arrives at St Louis Bus Station. Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company |
|---|---|---|---|---|
| 3:25 AM New | 7:05 AM | 3h 40m | Daily from Nov 4 | Greyhound Full timetable |
| 6:35 PM | 10:45 PM | 4h 10m | Daily | Greyhound Full timetable |
Route map
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Where to board in Springfield Where you get off in St. Louis The route of the busiest trip
Where to catch the bus in Springfield
Where the bus stops in St. Louis
- St Louis Bus Station Map of St Louis Bus Station (Google Maps)
Return trip: St. Louis to Springfield
Questions
How long is the bus from Springfield to St. Louis?
The fastest direct bus takes 3 hours 40 minutes.
What time is the first bus from Springfield to St. Louis?
The earliest departure is at 3:25 AM (Daily) and the last at 6:35 PM (Daily).
Which bus companies go from Springfield to St. Louis?
Greyhound runs direct buses on this route.
Where do I catch the bus in Springfield?
Buses to St. Louis leave from Springfield Cu Transit Center.