SD → WY · about 495 miles
Sioux Falls to Buffalo bus schedule
Jefferson Lines runs 7 direct buses a week from Sioux Falls to Buffalo. The fastest takes 10 hours; every bus leaves at 12:40 PM. The standard fare is $168 one way.
Timetable data from · Schedule last changed
- Buses a week
- 7
- Fastest trip
- 10h 00m
- Leaves at
- 12:40 PM
- Standard fare
- $168
A standard fare is the carrier's published one-way price. Many carriers price by demand, so the fare when you book can be higher or lower. Fares don't include any fees the carrier's ticket site may add; BusSchedules.com adds no fees.
Timetable
Every bus leaves from Sioux Falls and arrives at Buffalo. Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company | Ticket |
|---|---|---|---|---|---|
| 12:40 PM | 9:40 PM | 10h 00m | Daily | Jefferson Lines Full timetable | Book (carrier website) |
Route map
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Where to board in Sioux Falls Where you get off in Buffalo The route of the busiest trip
Where to catch the bus in Sioux Falls
- Sioux Falls Jefferson Lines bus stop Map of Sioux Falls Jefferson Lines bus stop (Google Maps)
Where the bus stops in Buffalo
- Buffalo bus stop Map of Buffalo bus stop (Google Maps)
Return trip: Buffalo to Sioux Falls
Questions
How long is the bus from Sioux Falls to Buffalo?
The fastest direct bus takes 10 hours.
How much is the bus from Sioux Falls to Buffalo?
The standard one-way fare with Jefferson Lines is $168. Many carriers price by demand, so the fare when you book can be higher or lower. Fares don't include any fees the carrier's ticket site may add; BusSchedules.com adds no fees.
What time is the first bus from Sioux Falls to Buffalo?
Every departure is at 12:40 PM (Daily).
Which bus companies go from Sioux Falls to Buffalo?
Jefferson Lines runs direct buses on this route.
Where do I catch the bus in Sioux Falls?
Buses to Buffalo leave from Sioux Falls Jefferson Lines bus stop.