WY → SD · about 495 miles
Buffalo to Sioux Falls bus schedule
Jefferson Lines runs 7 direct buses a week from Buffalo to Sioux Falls. The fastest takes 10 hours; every bus leaves at 7:20 AM. The standard fare is $168 one way.
Timetable data from · No schedule changes since at least
- Buses a week
- 7
- Fastest trip
- 10h 00m
- Leaves at
- 7:20 AM
- Standard fare
- $168
A standard fare is the carrier's published one-way price. Many carriers price by demand, so the fare when you book can be higher or lower. Fares don't include any fees the carrier's ticket site may add; BusSchedules.com adds no fees.
Timetable
Every bus leaves from Buffalo and arrives at Sioux Falls. Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company | Ticket |
|---|---|---|---|---|---|
| 7:20 AM | 6:20 PM | 10h 00m | Daily | Jefferson Lines Full timetable | Book (carrier website) |
Route map
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Where to board in Buffalo Where you get off in Sioux Falls The route of the busiest trip
Where to catch the bus in Buffalo
- Buffalo bus stop Map of Buffalo bus stop (Google Maps)
Where the bus stops in Sioux Falls
- Sioux Falls Jefferson Lines bus stop Map of Sioux Falls Jefferson Lines bus stop (Google Maps)
Return trip: Sioux Falls to Buffalo
Questions
How long is the bus from Buffalo to Sioux Falls?
The fastest direct bus takes 10 hours.
How much is the bus from Buffalo to Sioux Falls?
The standard one-way fare with Jefferson Lines is $168. Many carriers price by demand, so the fare when you book can be higher or lower. Fares don't include any fees the carrier's ticket site may add; BusSchedules.com adds no fees.
What time is the first bus from Buffalo to Sioux Falls?
Every departure is at 7:20 AM (Daily).
Which bus companies go from Buffalo to Sioux Falls?
Jefferson Lines runs direct buses on this route.
Where do I catch the bus in Buffalo?
Buses to Sioux Falls leave from Buffalo bus stop.