SD → WY · about 432 miles
Mitchell to Buffalo bus schedule
Jefferson Lines runs 7 direct buses a week from Mitchell to Buffalo. The fastest takes 8 hours 50 minutes; every bus leaves at 1:50 PM. The standard fare is $165 one way.
Timetable data from · Schedule last changed
- Buses a week
- 7
- Fastest trip
- 8h 50m
- Leaves at
- 1:50 PM
- Standard fare
- $165
A standard fare is the carrier's published one-way price. Many carriers price by demand, so the fare when you book can be higher or lower. Fares don't include any fees the carrier's ticket site may add; BusSchedules.com adds no fees.
Timetable
Every bus leaves from Mitchell and arrives at Buffalo. Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company | Ticket |
|---|---|---|---|---|---|
| 1:50 PM | 9:40 PM | 8h 50m | Daily | Jefferson Lines Full timetable | Book (carrier website) |
Route map
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Where to board in Mitchell Where you get off in Buffalo The route of the busiest trip
Where to catch the bus in Mitchell
- Mitchell Jefferson Lines bus stop Map of Mitchell Jefferson Lines bus stop (Google Maps)
Where the bus stops in Buffalo
- Buffalo bus stop Map of Buffalo bus stop (Google Maps)
Return trip: Buffalo to Mitchell
Questions
How long is the bus from Mitchell to Buffalo?
The fastest direct bus takes 8 hours 50 minutes.
How much is the bus from Mitchell to Buffalo?
The standard one-way fare with Jefferson Lines is $165. Many carriers price by demand, so the fare when you book can be higher or lower. Fares don't include any fees the carrier's ticket site may add; BusSchedules.com adds no fees.
What time is the first bus from Mitchell to Buffalo?
Every departure is at 1:50 PM (Daily).
Which bus companies go from Mitchell to Buffalo?
Jefferson Lines runs direct buses on this route.
Where do I catch the bus in Mitchell?
Buses to Buffalo leave from Mitchell Jefferson Lines bus stop.