FL → FL · about 227 miles
Port St. Lucie to Jacksonville bus schedule
Greyhound runs 7 direct buses a week from Port St. Lucie to Jacksonville. The fastest takes 6 hours 10 minutes; every bus leaves at 8:35 AM.
Timetable data from · No schedule changes since at least
- Buses a week
- 7
- Fastest trip
- 6h 10m
- Leaves at
- 8:35 AM
Timetable
Every bus leaves from Port St Lucie Park & Ride and arrives at Jacksonville Greyhound Bus Station. Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company |
|---|---|---|---|---|
| 8:35 AM | 2:45 PM | 6h 10m | Daily | Greyhound Full timetable |
Route map
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Where to board in Port St. Lucie Where you get off in Jacksonville The route of the busiest trip
Where to catch the bus in Port St. Lucie
- Port St Lucie Park & Ride Map of Port St Lucie Park & Ride (Google Maps)
Where the bus stops in Jacksonville
Return trip: Jacksonville to Port St. Lucie
Questions
How long is the bus from Port St. Lucie to Jacksonville?
The fastest direct bus takes 6 hours 10 minutes.
What time is the first bus from Port St. Lucie to Jacksonville?
Every departure is at 8:35 AM (Daily).
Which bus companies go from Port St. Lucie to Jacksonville?
Greyhound runs direct buses on this route.
Where do I catch the bus in Port St. Lucie?
Buses to Jacksonville leave from Port St Lucie Park & Ride.