FL → FL · about 227 miles
Jacksonville to Port St. Lucie bus schedule
Greyhound runs 7 direct buses a week from Jacksonville to Port St. Lucie. The fastest takes 6 hours 25 minutes; every bus leaves at 9:00 AM.
Timetable data from · No schedule changes since at least
- Buses a week
- 7
- Fastest trip
- 6h 25m
- Leaves at
- 9:00 AM
Timetable
Every bus leaves from Jacksonville Greyhound Bus Station and arrives at Port St Lucie Park & Ride. Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company |
|---|---|---|---|---|
| 9:00 AM | 3:25 PM | 6h 25m | Daily | Greyhound Full timetable |
Route map
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Where to board in Jacksonville Where you get off in Port St. Lucie The route of the busiest trip
Where to catch the bus in Jacksonville
Where the bus stops in Port St. Lucie
- Port St Lucie Park & Ride Map of Port St Lucie Park & Ride (Google Maps)
Return trip: Port St. Lucie to Jacksonville
Questions
How long is the bus from Jacksonville to Port St. Lucie?
The fastest direct bus takes 6 hours 25 minutes.
What time is the first bus from Jacksonville to Port St. Lucie?
Every departure is at 9:00 AM (Daily).
Which bus companies go from Jacksonville to Port St. Lucie?
Greyhound runs direct buses on this route.
Where do I catch the bus in Jacksonville?
Buses to Port St. Lucie leave from Jacksonville Greyhound Bus Station.