PA → MO · about 558 miles
Pittsburgh to St. Louis bus schedule
Greyhound runs 14 direct buses a week from Pittsburgh to St. Louis. The fastest takes 12 hours 55 minutes; the first bus leaves at 1:25 AM and the last at 8:00 PM.
Timetable data from · No schedule changes since at least
- Buses a week
- 14
- Fastest trip
- 12h 55m
- First bus
- 1:25 AM
- Last bus
- 8:00 PM
Timetable
Every bus leaves from Pittsburgh PA - Bus Station (PGB) and arrives at St Louis Bus Station. Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company |
|---|---|---|---|---|
| 1:25 AM | 3:10 PM | 14h 45m | Daily | Greyhound Full timetable |
| 8:00 PM | 7:55 AM +1 day | 12h 55m | Daily | Greyhound Full timetable |
Route map
The map needs JavaScript.
Where to board in Pittsburgh Where you get off in St. Louis The route of the busiest trip
Where to catch the bus in Pittsburgh
Where the bus stops in St. Louis
- St Louis Bus Station Map of St Louis Bus Station (Google Maps)
Return trip: St. Louis to Pittsburgh
Questions
How long is the bus from Pittsburgh to St. Louis?
The fastest direct bus takes 12 hours 55 minutes.
What time is the first bus from Pittsburgh to St. Louis?
The earliest departure is at 1:25 AM (Daily) and the last at 8:00 PM (Daily).
Which bus companies go from Pittsburgh to St. Louis?
Greyhound runs direct buses on this route.
Where do I catch the bus in Pittsburgh?
Buses to St. Louis leave from Pittsburgh PA - Bus Station (PGB).