AL → MS · about 259 miles
Opelika to Biloxi bus schedule
Greyhound runs 14 direct buses a week from Opelika to Biloxi. The fastest takes 5 hours 55 minutes; the first bus leaves at 9:05 AM and the last at 9:40 PM.
Timetable data from · No schedule changes since at least
- Buses a week
- 14
- Fastest trip
- 5h 55m
- First bus
- 9:05 AM
- Last bus
- 9:40 PM
Timetable
Every bus leaves from Opelika 4Th Street Station and arrives at Biloxi MS (BIG). Times are local to each stop. Timetables published by tds.ai, refreshed October 15, 2026. Schedules change, so check times when you book.
| Departs | Arrives | Duration | Days | Bus company |
|---|---|---|---|---|
| 9:05 AM | 3:05 PM | 6h 00m | Daily | Greyhound Full timetable |
| 9:40 PM | 3:35 AM +1 day | 5h 55m | Daily | Greyhound Full timetable |
Route map
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Where to board in Opelika Where you get off in Biloxi The route of the busiest trip
Where to catch the bus in Opelika
- Opelika 4Th Street Station Map of Opelika 4Th Street Station (Google Maps)
Where the bus stops in Biloxi
Return trip: Biloxi to Opelika
Questions
How long is the bus from Opelika to Biloxi?
The fastest direct bus takes 5 hours 55 minutes.
What time is the first bus from Opelika to Biloxi?
The earliest departure is at 9:05 AM (Daily) and the last at 9:40 PM (Daily).
Which bus companies go from Opelika to Biloxi?
Greyhound runs direct buses on this route.
Where do I catch the bus in Opelika?
Buses to Biloxi leave from Opelika 4Th Street Station.